Dimetridazole

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Structural formula
Structural formula of dimetridazole
General
Non-proprietary name Dimetridazole
other names

1,2-dimethyl-5-nitroimidazole

Molecular formula C 5 H 7 N 3 O 2
External identifiers / databases
CAS number 551-92-8
EC number 209-001-2
ECHA InfoCard 100.008.184
PubChem 3090
ChemSpider 2980
Wikidata Q5277356
Drug information
ATC code

Q P51AA07

Drug class

antibiotic

Mechanism of action

DNA strand breaks

properties
Molar mass 141.13 g mol −1
Physical state

firmly

Melting point

138-138 ° C

solubility

sparingly soluble in water and ether ; freely soluble in ethanol 96%

safety instructions
Please note the exemption from the labeling requirement for drugs, medical devices, cosmetics, food and animal feed
GHS labeling of hazardous substances
07 - Warning

Caution

H and P phrases H: 315-319-335
P: 261-305 + 351 + 338
As far as possible and customary, SI units are used. Unless otherwise noted, the data given apply to standard conditions .

Dimetridazole (trade name chevi-col ) is an antibiotic from the nitroimidazole group . In Germany it is approved for the treatment of carrier pigeons against yellow button (infestation with Trichomonas gallinae ), the use in food-producing animals is prohibited. The active ingredient can also be used in other birds to combat trichomonads and Giardia intestinalis . It can also be used for trichomonads and giardia infections of small pets ( guinea pigs , chinchillas , rabbits ) and infections with Entamoeba invadens in reptiles .

The maximum plasma concentration is reached in fasting pigeons after 1 and in fed pigeons after 2.3 hours. The plasma half-life is 3.9 hours. The bioavailability in fasting animals is 83.8%. The main metabolite is 1-methyl-5-nitroimidazol-2-ylmethyl hydrogen sulfate, which, however, probably has no activity against Trichomonas gallinae . The active ingredient and its metabolites are excreted in the urine, feces and exhaled air.

Individual evidence

  1. ↑ a b c d Entry on dimetridazole at Vetpharm, accessed on May 25, 2017.
  2. ↑ a b Datasheet Dimetridazole from Sigma-Aldrich , accessed on October 13, 2014 ( PDF ).
  3. ↑ vetidata (fee-based specialist information service).
  4. ↑ P. Zwart: Snakes . In: K. Gabrisch, P. Zwart (ed.): Diseases of Heimtiere , Hannover (Schlütersche) 3rd edition 1995, p. 772, ISBN 387706325X .