Diprenorphine

Structural formula
General
Non-proprietary name	Diprenorphine
other names	(5 α , 7 α ) -17- (cyclopropylmethyl) -4,5-epoxy-18,19-dihydro-3-hydroxy-6-methoxy-α, α-dimethyl-6,14-ethenomorphinane-7-methanol ( IUPAC )
Molecular formula	C 26 H 35 NO 4
Brief description	white solid
External identifiers / databases
EC number	238-325-7
ECHA InfoCard	100,034,826
PubChem	443408
ChemSpider	391634
DrugBank	DB01548
Wikidata	Q424009
Drug information
ATC code	Q V03AB92
Drug class	Opioid antagonist , antidote
Mechanism of action	Competitive inhibition of opioid receptors
properties
Molar mass	425.56 g · mol -1
Physical state	firmly
Melting point	192-193 ° C
safety instructions
	Please note the exemption from the labeling requirement for drugs, medical devices, cosmetics, food and animal feed
GHS labeling of hazardous substances Caution
H and P phrases	H: 302-312-315-319-332-335
	P: 261-280-305 + 351 + 338
Toxicological data	316 mg kg −1 ( LD 50 , mouse , sc , hydrochloride)
	As far as possible and customary, SI units are used. Unless otherwise noted, the data given apply to standard conditions .

Diprenorphine (Revivon, M5050) is an opioid - antagonist . It is used to counteract the effects of extremely potent opioids such as etorphine or carfentanyl , which are used in veterinary medicine to stun large animals. Diprenorphine is the strongest commercially available opioid antagonist. It is used to wake up animals that have been anesthetized with the aforementioned opioids. Because diprenorphine also has an agonistic effect in part, it is not used in humans, where naloxone or naltrexone are the agents of choice. The potency as an antagonist is given as 100 times that of nalorphine ( N- allyl normorphine, an opioid antagonist that has not been used for a long time). No veterinary drugs based on diprenorphine are approved in Germany.

Individual evidence

↑ ^a ^b ^c ^d Datasheet Diprenorphine from Sigma-Aldrich , accessed on March 28, 2011 ( PDF ).
^ Entry on diprenorphine in the ChemIDplus database of the United States National Library of Medicine (NLM) .
↑ Eberhard Schröder, Clemens Rufer, Ralph Schmiechen: Arzneimittelchemie I , Georg Thieme, 1976, ISBN 3-13-520601-7 .

[Sigma-1] Datasheet Diprenorphine from Sigma-Aldrich , accessed on March 28, 2011 ( PDF ).

[ChemIDplus-2] Entry on diprenorphine in the ChemIDplus database of the United States National Library of Medicine (NLM) .

[3] Eberhard Schröder, Clemens Rufer, Ralph Schmiechen: Arzneimittelchemie I , Georg Thieme, 1976, ISBN 3-13-520601-7 .