Doramectin
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Non-proprietary name | Doramectin | ||||||||||||||||||
other names |
25-Cyclohexyl-5- O- dimethyl-25-de (1-methylpropyl) avermectin A 1a |
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Molecular formula | C 50 H 74 O 14 | ||||||||||||||||||
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Mechanism of action |
Increase of the membrane permeability for chloride |
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properties | |||||||||||||||||||
Molar mass | 899.11 g · mol -1 | ||||||||||||||||||
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Toxicological data | |||||||||||||||||||
As far as possible and customary, SI units are used. Unless otherwise noted, the data given apply to standard conditions . |
Doramectin is a macrocyclic lactone ( macrolide ) and glycoside . As a medicinal substance, it belongs to the group of avermectins (fermentation product of Streptomyces avermitilis ) and is closely related to ivermectin , but with an additional cyclohexyl group it is longer effective. Doramectin is used in veterinary medicine as an anti-parasitic agent.
Chemical properties and pharmacology
Doramectin is highly lipophilic and good in many organic solvents, but hardly soluble in water.
Like all avermectins increasing the membrane permeability of nerve cells in nematodes and the nerve and muscle cells in arthropods for chloride - ion ( see also ivermectin ). Doramectin therefore acts as a broad-spectrum anti-parasitic agent and has both worm-killing (vermicidal) and insect and mite-killing properties. On the other hand, the drug is not effective against suckers and tapeworms .
Doramectin is mostly administered subcutaneously and is distributed in all tissues, with the highest concentration in adipose tissue. When applied topically , the bioavailability is significantly lower. The plasma half-life is 10 days. It is excreted primarily through the bile and then through the faeces.
Contraindications
Doramectin is well tolerated, not carcinogenic or mutagenic. It can also be used in pregnant and young animals. However , the product must not be used in dogs with MDR1 defects .
Trade names
Dectomax ad us. vet. , Dectomax 0.5% pour-on solution ad us. vet. , Doramec LA , Doraquest LA Oral Gel
Web links
- Entry on Doramectin at Vetpharm, accessed July 30, 2012.
Individual evidence
- ↑ a b c Datasheet Doramectin from Sigma-Aldrich , accessed on May 14, 2017 ( PDF ).