Doxifluridine

Structural formula
General
Non-proprietary name	Doxifluridine
other names	5'-deoxy-5-fluorouridine 5-DFUR Furtulon
Molecular formula	C 9 H 11 FN 2 O 5
External identifiers / databases
CAS number 3094-09-5 EC number 221-440-1 ECHA InfoCard 100.019.491 PubChem 18343 Wikidata Q1253473
Drug information
ATC code	L01 BC00
Drug class	Cytostatic
properties
Molar mass	246.19 g mol −1
Physical state	firmly
Melting point	190 ° C
safety instructions
Please note the exemption from the labeling requirement for drugs, medical devices, cosmetics, food and animal feed GHS labeling of hazardous substances no GHS pictograms H and P phrases H: no H-phrases P: no P-phrases
Toxicological data	3390 mg kg −1 ( LD 50 ,  rat ,  oral )
As far as possible and customary, SI units are used. Unless otherwise noted, the data given apply to standard conditions .

Doxifluridine is an analogue of the nucleoside uridine and a drug that is used as a cytostatic in chemotherapy .

Pharmacokinetics

Doxifluridine is metabolized to 5-fluorouracil and 5,6-dihydrofluoruracil. Oral bioavailability is 34–47%.

Side effects

Doxifluridine is cell damaging. It is carcinogenic (it can cause cancer), mutagenic (can cause hereditary damage), and teratogenic (can cause harm to the unborn child). Depending on the dose, diarrhea, nausea, vomiting, loss of appetite, irritation of the mucous membranes and blood changes can occur.

Individual evidence

1. ↑ ^{a b} Entry on doxifluridine in the ChemIDplus database of the United States National Library of Medicine (NLM) .
2. ↑ ^{a b} Doxifluridine data sheet from Sigma-Aldrich , accessed on February 3, 2011 ( PDF ).

This article is about a health issue. It is not used for self-diagnosis and does not replace a diagnosis by a doctor. Please note the information on health issues !