Drofenin

from Wikipedia, the free encyclopedia
Structural formula
Structure of drofenine
General
Non-proprietary name Drofenin
other names
  • Cycloadiphenine
  • Hexahydroadiphenine
  • α-Cyclohexylphenylacetic acid 2- (diethylamino) ethyl ester
  • 2-diethylaminoethyl-2-cyclohexyl-2-phenyl acetate ( IUPAC )
Molecular formula C 20 H 31 NO 2
Brief description
  • light yellow, viscous mass
  • white, finely crystalline powder (hydrochloride)
External identifiers / databases
CAS number
  • 1679-76-1 (Drofenin)
  • 548-66-3 (monohydrochloride)
EC number 605-497-3
ECHA InfoCard 100.114.553
PubChem 3166
Wikidata Q1259495
Drug information
ATC code

A03 EA05 , A03 DA12

Drug class

Antispasmodic

Mechanism of action

Anticholinergic

properties
Molar mass 317.47 g mol −1
Physical state

firmly

Melting point

145–147 ° C (hydrochloride)

boiling point

158 ° C at 19.5 Pa

safety instructions
Please note the exemption from the labeling requirement for drugs, medical devices, cosmetics, food and animal feed
GHS labeling of hazardous substances
no GHS pictograms
H and P phrases H: no H-phrases
P: no P-phrases
Toxicological data
As far as possible and customary, SI units are used. Unless otherwise noted, the data given apply to standard conditions .

Drofenin [trade name: Spasmoplus (A) ] is a drug , which as anticonvulsant used to be Ciba patented 1,941th It is an anticholinergic that acts on both the nerves and the muscle fibers (neurotropic- musculotropic effect). Drofenine also acts as a FIASMA (functional inhibitor of acid sphingomyelinase ).

From a chemical point of view, it is a derivative of phenylacetic acid , which is related to adiphenin .

The drug is used in the form of the hydrochloride .

literature

  • HPT Ammon (Ed.): Hunnius Pharmaceutical Dictionary . 9th edition, Walter de Gruyter, Berlin a. New York, 2004.
  • HJ Roth, H. Fenner: Medicines . Thieme, Stuttgart a. New York, 1988. p. 404.

Individual evidence

  1. ↑ a b c d e f Entry on Drofenin. In: Römpp Online . Georg Thieme Verlag, accessed on May 29, 2014.
  2. ↑ a b c Data sheet Drofenine hydrochloride from Sigma-Aldrich , accessed on October 20, 2016 ( PDF ).
  3. ↑ Kornhuber J, Muehlbacher M, Trapp S, Pechmann S, Friedl A, Reichel M, Mühle C, Terfloth L, Groemer T, Spitzer G, Liedl K, Gulbins E, Tripal P: Identification of novel functional inhibitors of acid sphingomyelinase . In: PLoS ONE . 6, No. 8, 2011, p. E23852. doi : 10.1371 / journal.pone.0023852 .
  4. ↑ External identifiers of or database links to adiphenin : CAS number: 64-95-9, EC number: 200-599-0, ECHA InfoCard: 100.000.545 , PubChem : 2031 , ChemSpider : 1953 , Wikidata : Q4057596 .
  5. ↑ External identifiers or database links for drofenine hydrochloride : CAS number: 548-66-3, EC number: 208-954-1, ECHA InfoCard: 100.008.141 , PubChem : 92806 , ChemSpider : 83778 , Wikidata : Q27284253 .