Sodium 4- (propoxycarbonyl) phenate

Structural formula
General
Surname	Sodium 4- (propoxycarbonyl) phenate
other names	Propyl 4-hydroxybenzoate sodium salt; Propyl 4-hydroxybenzoate, sodium salt; Sodium propyl 4-hydroxybenzoate ( Ph.Eur. ); Propyl paraben sodium salt; Sodium propyl paraben; SODIUM PROPYLPARABEN ( INCI ) ; E 217;
Molecular formula	C 10 H 11 NaO 3
Brief description	colorless and odorless solid
External identifiers / databases
EC number	252-488-1
ECHA InfoCard	100.047.702
PubChem	23679044
ChemSpider	34047
Wikidata	Q3963919
properties
Molar mass	202.19 g mol −1
Physical state	firmly
density	1.24 g cm −3 (25 ° C)
Melting point	302 ° C
solubility	very soluble in water (> 1000 g l −1 at 23 ° C); practically insoluble in fixed oils; Slightly soluble in ethanol 96%, practically insoluble in dichloromethane ;
safety instructions
GHS labeling of hazardous substances danger
H and P phrases	H: 318
	P: 280-305 + 351 + 338-313
Toxicological data	> 5000 mg kg −1 ( LD 50 , rat , oral )
	As far as possible and customary, SI units are used. Unless otherwise noted, the data given apply to standard conditions .

Sodium 4- (propoxycarbonyl) phenolate is a chemical compound belonging to the group of paraben derivatives . It is the sodium salt of propyl paraben .

Occurrence

Sodium 4- (propoxycarbonyl) phenolate has been detected in tobacco .

properties

Sodium 4- (propoxycarbonyl) phenolate is a colorless and odorless solid that is very soluble in water. It decomposes at temperatures above 310 ° C.

use

Sodium 4- (propoxycarbonyl) phenolate is used as a preservative ( bactericide , fungicide ) in food, pharmaceuticals, medical devices, cosmetics and technical products.

Since 2006, E 217 has not been approved as a food additive in the EU or Switzerland.

For the preservation of pharmaceuticals in the EU, taking into account the effects of propyl 4-hydroxybenzoate (propyl paraben, acid form) on the female reproductive system found in animal studies, 2 mg / kg body weight per day (calculated as propyl paraben) is the permitted daily dose for use at Children and adults.

Individual evidence

↑ Entry on SODIUM PROPYLPARABEN in the CosIng database of the EU Commission, accessed on December 28, 2019.
↑ ^a ^b ^c ^d ^e ^f ^g ^h ⁱ Data sheet sodium 4- (propoxycarbonyl) phenolate (PDF) from Merck , accessed on December 11, 2019.
↑ Michael Ash: Handbook of Preservatives . Synapse Info Resources, 2004, ISBN 978-1-890595-66-1 , pp. 510 ( limited preview in Google Book Search).
↑ European Pharmacopoeia, 8th edition, Grundwerk 2014, p. 4270.
↑ Alan Rodgman, Thomas A. Perfetti: The Chemical Components of Tobacco and Tobacco Smoke . CRC Press, 2016, ISBN 978-1-4665-1552-9 , pp. 2182 ( limited preview in Google Book Search).
↑ Marina Bährle-Rapp: Springer Lexicon Cosmetics and Body Care . Springer-Verlag, 2013, ISBN 978-3-662-09985-8 , pp. 391 ( limited preview in Google Book search).
^ GWA Milne: Gardner's Commercially Important Chemicals Synonyms, Trade Names, and Properties . John Wiley & Sons, 2005, ISBN 0-471-73661-9 , pp. 527 ( limited preview in Google Book search).
↑ Pedro A. Moscoso-Ramírez, Clara Montesinos-Herrero, Lluís Palou: Antifungal activity of sodium propylparaben alone or in combination with low doses of imazalil against Penicillium decay on citrus fruit. In: European Journal of Plant Pathology. 140, 2014, p. 145, doi : 10.1007 / s10658-014-0450-5 .
↑ Directive 2006/52 / EC of the European Parliament and of the Council of July 5, 2006 amending Directive 95/2 / EC on food additives other than colors and sweeteners and Directive 94/35 / EC on sweeteners used in food allowed . In: Official Journal of the European Union. P. 13, 3. a) i), July 26, 2006.

↑ Reflection paper on the use of methyl- and propylparaben as excipients in human medicinal products for oral use (PDF), Committee on Medicinal Products for Human Use of the European Medicines Agency, October 2015 (English).

[CosIng-1] Entry on SODIUM PROPYLPARABEN in the CosIng database of the EU Commission, accessed on December 28, 2019.

[Merck-2] ↑ ^a ^b ^c ^d ^e ^f ^g ^h ⁱ Data sheet sodium 4- (propoxycarbonyl) phenolate (PDF) from Merck , accessed on December 11, 2019.

[Michael_Ash-3] Michael Ash: Handbook of Preservatives . Synapse Info Resources, 2004, ISBN 978-1-890595-66-1 , pp. 510 ( limited preview in Google Book Search).

[4] European Pharmacopoeia, 8th edition, Grundwerk 2014, p. 4270.

[Alan_Rodgman,_Thomas_A._Perfetti-5] Alan Rodgman, Thomas A. Perfetti: The Chemical Components of Tobacco and Tobacco Smoke . CRC Press, 2016, ISBN 978-1-4665-1552-9 , pp. 2182 ( limited preview in Google Book Search).

[Marina_Bährle-Rapp-6] Marina Bährle-Rapp: Springer Lexicon Cosmetics and Body Care . Springer-Verlag, 2013, ISBN 978-3-662-09985-8 , pp. 391 ( limited preview in Google Book search).

[G._W._A._Milne-7] GWA Milne: Gardner's Commercially Important Chemicals Synonyms, Trade Names, and Properties . John Wiley & Sons, 2005, ISBN 0-471-73661-9 , pp. 527 ( limited preview in Google Book search).

[DOI10.1007/s10658-014-0450-5-8] Pedro A. Moscoso-Ramírez, Clara Montesinos-Herrero, Lluís Palou: Antifungal activity of sodium propylparaben alone or in combination with low doses of imazalil against Penicillium decay on citrus fruit. In: European Journal of Plant Pathology. 140, 2014, p. 145, doi : 10.1007 / s10658-014-0450-5 .

[9] Directive 2006/52 / EC of the European Parliament and of the Council of July 5, 2006 amending Directive 95/2 / EC on food additives other than colors and sweeteners and Directive 94/35 / EC on sweeteners used in food allowed . In: Official Journal of the European Union. P. 13, 3. a) i), July 26, 2006.

[10] Reflection paper on the use of methyl- and propylparaben as excipients in human medicinal products for oral use (PDF), Committee on Medicinal Products for Human Use of the European Medicines Agency, October 2015 (English).