Escherichia virus T5

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Escherichia virus T5
Systematics
Classification : Viruses
Area : Duplodnaviria
Empire : Heunggongvirae
Phylum : Uroviricota
Class : Caudoviricetes
Order : Caudovirales
Family : Demerecviridae
Subfamily : Markadamsvirinae
Genre : Tequintavirus
Type : Escherichia virus T5
Taxonomic characteristics
Genome : dsDNA linear
Baltimore : Group 1
Symmetry : icosahedral, tailed
Cover : no
Scientific name
Escherichia virus T5
Short name
T5
Left
NCBI  Taxonomy: 10726
ViralZone ( ExPASy , SIB): 511 (gender)
ICTV Taxon History: 201851328


The species Escherichia virus T5 ( scientifically Escherichia virus T5 , with the bacteriophage T5 virus ) is a member of the genus Teqintavirus (formerly called T5virus or T5likevirus ) within the family Demerecviridae , subfamily Markadamsvirinae . These viruses are no longer listed in the Siphoviridae family by ICTV since March 2020 . They specifically infect bacteria of the species Escherichia coli ( coli bacteria ) and are therefore classified (non- taxonomically ) as bacteriophages (bacterial viruses).

Structure and genome

The virions (virus particles) of this species have a head with an icosahedral capsid 90  nm in diameter and a 250 nm long flexible, non- contractile tail. The capsid contains the double-stranded DNA - the genome of the phage with a length of 121750  bp (base pairs).

Propagation cycle

At the beginning of the infection of a coli bacterium, the T5 virion binds with its receptor binding protein pb5 to the ferrichrome transporter FhuA (receptor) on the outer membrane of the host cell . The binding triggers structural changes in pb5 and ultimately leads to the release of the DNA from the phage capsid and injection into the bacterial cell.

The release of the newly formed virions occurs typically for the members of the genus Tequintavirus by lysis .

Individual evidence

  1. ↑ a b c d ICTV: ICTV Taxonomy history: Enterobacteria phage T4 , EC 51, Berlin, Germany, July 2019; Email ratification March 2020 (MSL # 35)
  2. ↑ a b c ICTV: ICTV Taxonomy history: Tequintavirus , EC 51, Berlin, Germany, July 2019; Email ratification March 2020 (MSL # 35)
  3. ↑ ICTV Master Species List 2018b v2 MSL # 34v, March 2019
  4. ↑ Mart Krupovic, et 1l. : To rename all (522) existing bacterial virus and 2 archaeal virus species ( en ) May 2015. Retrieved February 27, 2020.
  5. ↑ a b c SIB: Tequintavirus on: ExPASy ViralZone
  6. ↑ G. Effantin, P. Boulanger, E. Neumann, L. Letellier, J. F. Conway: Bacteriophage T5 structure reveals similarities with HK97 and T4 suggesting evolutionary relationships , in: J Mol Biol. (2006) 361, pp. 993-1002, PMID 16876823
  7. ↑ A. Flayhan, F. Wien, M. Paternostre, P. Boulanger, C. Breyton: New insight into pb5, the receptor binding protein of bacteriophage T5, and its interaction with its Escherichia coli receptor FhuA . In: Biochemistry . 94, No. 9, September 2012, pp. 1982-1989. doi : 10.1016 / j.biochi.2012.05.021 . PMID 22659573 .
  8. ↑ H. Basit, K. Shivaji Sharma, A. Van der Heyden, C. Gondran, C. Breyton, P. Dumy, F. M. Winnik, P. Labbé: Amphipol mediated surface immobilization of FhuA: a platform for label-free detection of the bacteriophage protein pb5 . In: Chemical Communications (Cambridge, England) . 48, No. 48, May 11, 2012, pp. 6037-6039. doi : 10.1039 / c2cc31107k . PMID 22576748 .

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