Euparin

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Structural formula
Structural formula of Euparin
General
Surname Euparin
other names
  • 5-acetyl-6-hydroxy-2-isopropylbenzofuran
  • 1- (6-hydroxy-2-prop-1-en-2-yl-1-benzofuran-5-yl) ethanone
Molecular formula C 13 H 12 O 3
Brief description

white odorless solid

External identifiers / databases
CAS number 532-48-9
PubChem 119039
ChemSpider 106366
Wikidata Q27135902
properties
Molar mass 216.236 g mol −1
Physical state

firmly

Melting point

121-122 ° C

safety instructions
GHS labeling of hazardous substances
07 - Warning

Caution

H and P phrases H: 315-319-335
P: 280-261-305 + 351 + 338-321-405-501
As far as possible and customary, SI units are used. Unless otherwise noted, the data given apply to standard conditions .

Euparin is a chemical compound from the group of benzofurans . Euparin occurs in various plant species of the tribe Eupatorieae , including the genus Eupatorium ( Eupatorium buniifolium , Eupatorium chinensis , Eupatorium purpureum ), but also in Helianthus tuberosus , Petasites albus (73% of the oil), Ligularia caloxantha , Ligularia quularia stenervisce and Helianthus .

Euparin has antiviral effects against the poliovirus in the plaque assay .

Individual evidence

  1. ↑ a b c d e LGC: Safety data sheet Euparin ( Memento from March 10, 2018 in the Internet Archive )
  2. ↑ Ahmed Mustafa: Benzofurans. John Wiley & Sons, 2009, ISBN 978-0-470-18850-7 , p. 299.
  3. ↑ a b M. F. Visintini Jaime, RH Campos, VS Martino, LV Cavallaro, LV Muschietti: Antipoliovirus Activity of the Organic Extract of Eupatorium buniifolium: Isolation of Euparin as an Active Compound. In: Evidence-based complementary and alternative medicine: eCAM. Volume 2013, 2013, p. 402364, doi : 10.1155 / 2013/402364 , PMID 23956770 , PMC 3730360 (free full text).
  4. ↑ XL Xie, XJ Xu, RM Li, JZ Wan, CY Xie, DP Yang, X. Chen: Isolation and simultaneous determination of two benzofurans in Radix Eupatorii Chinensis. In: Natural Product Research . Volume 24, number 19, November 2010, pp. 1854-1860, doi : 10.1080 / 14786419.2010.482935 , PMID 21104532 .
  5. ↑ S. Habtemariam: Anti-inflammatory activity of the herbal antirheumatic drug, gravel root (Eupatorium purpureum): Further biological activities and constituents'. In: Phytotherapy research: PTR. Volume 15, Number 8, December 2001, pp. 687-690, PMID 11746861 .
  6. ^ NS Radulović, MR Đorđević: Chemical composition of the tuber essential oil from Helianthus tuberosus L. (Asteraceae). In: Chemistry & biodiversity. Volume 11, number 3, March 2014, pp. 427-437, doi : 10.1002 / cbdv.201300323 , PMID 24634072 .
  7. ↑ M. Mohammadi, M. Yousefi, Z. Habibi, D. Dastan: Chemical composition and antioxidant activity of the essential oil of aerial parts of Petasites albus from Iran: a good natural source of euparin. In: Natural Product Research . Volume 26, Number 4, 2012, pp. 291-297, doi : 10.1080 / 14786410903374819 , PMID 21416453 .
  8. ^ SY Shi, MH Hu, DY Wu, CX Zhou, JX Mo, JH Xu, LR Chen, H. Dou, H. Peng, XJ Hao, J. Stöckigt, Y. Zhao: A new dibenzofuran and other constituents from Ligularia caloxantha , a Chinese medicinal plant. In: Natural Product Research . Volume 22, Number 7, May 2008, pp. 628-632, doi : 10.1080 / 14786410701614218 , PMID 18569702 .
  9. ↑ K. Toyoda, Y. Yaoita, M. Kikuchi: Three new dimeric benzofuran derivatives from the roots of Ligularia stenocephala MATSUM. et KOIDZ. In: Chemical & pharmaceutical bulletin. Volume 53, Number 12, December 2005, pp. 1555-1558, PMID 16327188 .
  10. ↑ P. Castañeda, L. Gómez, R. Mata, B. Lotina-Hennsen, AL Anaya, R. Bye: Phytogrowth-inhibitory and antifungal constituents of Helianthella quinquenervis. In: Journal of natural products. Volume 59, Number 3, March 1996, pp. 323-326, doi : 10.1021 / np960199m , PMID 8882437 .