Frederick P. Li

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Frederick Pei Li (born May 7, 1940 in Guangzhou , China , † June 12, 2015 in Brookline , Massachusetts , USA ) was a Sino-American epidemiologist and cancer researcher . He is considered a pioneer in cancer genetics.

Li's father, Han Hun Li, was a general in the Sino-Japanese War . The family emigrated to the United States when Frederick Li was seven years old. He grew up in New York City , where his parents ran a Chinese restaurant. Li graduated from the New York University a Bachelor in Physics in 1965 at the University of Rochester an MD as graduation from medical school and 1967 at the Georgetown University a Master in Demography . From 1967 he worked at the National Cancer Institute , where he researched familial accumulations of cancer . From the early 1970s, Li was at the Dana-Farber Cancer Institute , where he became head of the epidemiology department in 1991. He was Professor of Cancer Epidemiology at the Harvard School of Public Health and Professor at Harvard Medical School . In 2008 he retired.

The Li-Fraumeni syndrome is named after him and Joseph F. Fraumeni , a rare hereditary disease that is associated with a very high risk of developing cancer. Fraumeni and Li were the first to describe the syndrome in 1969 and in 1990 they described its most common cause, a mutation in the p53 gene. Fraumeni and Li received the 1995 Charles S. Mott Prize from the General Motors Cancer Research Foundation .

Li died in 2015 of complications from his Alzheimer's disease . He was married to Elaine Shiang; the couple had three children.

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Individual evidence

  1. ^ Li-Fraumeni syndrome.  In: Online Mendelian Inheritance in Man . (English)
  2. General Motors Cancer Research Awards Laureates 1979–1998 (PDF; 148 kB) at aacrjournals.org; accessed on February 23, 2018.