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Structural formula
Structural formula of HEPPS
Surname 4- (2-Hydroxyethyl) -piperazine- 1-propanesulfonic acid (HEPPS)
other names
  • N-2-Hydroxyethylpiperazine-N'-3-propanesulfonic acid
  • EPPS
Molecular formula C 9 H 20 N 2 O 4 S
Brief description

white odorless solid

External identifiers / databases
CAS number 16052-06-5
EC number 240-198-8
ECHA InfoCard 100.036.528
PubChem 85255
ChemSpider 76886
Wikidata Q1563525
Molar mass 252.33 g mol −1
Physical state


Melting point

242 ° C (decomposition)

pK s value

8.00 (20 ° C)


soluble in water (25.2 g / l at 20 ° C)

safety instructions
GHS labeling of hazardous substances
no GHS pictograms
H and P phrases H: no H-phrases
P: no P-phrases
As far as possible and customary, SI units are used. Unless otherwise noted, the data given apply to standard conditions .

HEPPS is an abbreviation for 4- (2-hydroxyethyl) piperazine-1-propanesulfonic acid , a buffer substance from the group of Good buffers .

Chemical properties

HEPPS is a synthetic pH buffer . It is used as a buffer solution in biochemistry and molecular biology. HEPPS has an acid constant of pK s  = 8.00 (at 20 ° C) and has a good buffer capacity between pH  7.6 to 8.6.

Physiological properties

HEPPS appears to promote the dissolution of oligomers and plaques of beta-amyloid proteins in the hippocampus of the brain of Alzheimer's mice. For this purpose, HEPPS can simply be added to the drinking water, as it can cross the blood-brain barrier due to its small size ( molecular mass ) and as a zwitterion . In mice, the ability to traverse labyrinths improved because they were better able to remember the different paths through the individual labyrinths. To what extent these results can be transferred to humans remains to be seen.


  1. a b c d e data sheet EPPS, 99% at AlfaAesar, accessed on December 25, 2019 ( PDF )(JavaScript required) .
  2. M. Holtzhauer, V. Hahn: Biochemical laboratory methods. Working regulations and tables , 2nd edition, Springer Verlag, 1997. S. 194, ISBN 3-540-19267-0 .
  3. Biological Buffers. Applicher, accessed on November 14, 2017 .
  4. Ian Sample: Taurine-like chemical restores cognitive function in mice with Alzheimer. In: The Guardian Online. December 8, 2015, accessed December 10, 2015 .
  5. Hye Yun Kim, Hyunjin Vincent Kim, Seonmi Jo, C. Justin Lee, Seon Young Choi, Dong Jin Kim, YoungSoo Kim: EPPS rescues hippocampus-dependent cognitive deficits in APP / PS1 mice by disaggregation of amyloid-β oligomers and plaques. In: Nature Communications. 6, 2015, p. 8997, doi : 10.1038 / ncomms9997 .

Web links

See also