Henry A. Lardy

Henry Arnold Lardy (born August 19, 1917 in Roslyn , South Dakota , † August 4, 2010 ) was an American biochemist at the University of Wisconsin-Madison .

Life

Lardy acquired in 1939 a bachelor's degree in chemistry and dairying (dairy science) at the South Dakota State University and both a 1941 Masters and 1943 a Ph.D. in Biochemistry from the University of Wisconsin . As a postdoctoral fellow , he worked with Herman Fischer at the University of Toronto before receiving a first professorial position at the University of Wisconsin in 1945 and a full professorship in biochemistry at the Enzyme Institute there in 1950 . In 1988 he retired , but remained scientifically active until a few months before his death.

In one of his earliest papers, Lardy described a method for treating selenium poisoning in animals that was also used successfully in humans. Later he mainly dealt with cellular respiration . He researched the enzymes that catalyze the supply of adenosine triphosphate (ATP) and was able to determine that these need potassium to function and are thermodynamically stable . He clarified the chemical mechanisms of numerous enzymes that are involved in biological processes. In the 1940s, together with Paul H. Phillips, he developed a nutrient medium made from egg yolk and phosphate buffer , with which the semen of various breeding animals was made (limited) storable, which made artificial insemination widely available in animal breeding and the metabolism of spermatozoa could be studied. In these investigations, Lardy was able to show that 2,4-dinitrophenol decouples the oxidative phosphorylation . In addition, he refuted the existence of glycolysis without phosphates and showed the function of biotin as a binder for carbon dioxide in organic structures ( prosthetic group of carboxylases ). Lardy's late work looked at the effects of steroids on weight loss , memory, and cholesterol levels .

Lardy was married to Annrita Lardy and the couple had four children.

Awards

Lardy has received several awards for his scientific work. He received the Pfizer Award in Enzyme Chemistry in 1949 , the Wolf Prize in Agricultural Science in 1981 , the Amory Prize from the American Academy of Arts and Sciences in 1984 and the William C. Rose Award from the American Society for Biochemistry and Molecular Biology (ASBMB) in 1988 . In 1958 he was elected a member of the National Academy of Sciences , in 1965 in the American Academy of Arts and Sciences and in 1976 in the American Philosophical Society .

Individual evidence

1. ^ ^{A b} Doug Erickson: Noted University of Wisconsin-Madison researcher Henry Lardy dies at 92. In: host.madison.com. August 6, 2010, accessed February 13, 2017 . 
2. ^ Nicole Kresge, Robert D. Simoni, Robert L. Hill: Henry Lardy's Contributions to Understanding the Metabolic Pathway. In: Journal of Biological Chemistry . May 20, 2005, accessed February 13, 2017 . 
3. ^ UW-Madison biochemist Henry Lardy dies at age 92. In: news.wisc.edu. August 6, 2010, accessed February 13, 2017 . 
4. ↑ Pfizer Award in Enzyme Chemistry (PDF, 48 kB) in Section Biochemistry (Biological Chemistry) of the American Chemical Society (divbiolchem.org); accessed on February 13, 2017.
5. ^ Henry A. Lardy. In: wolffund.org.il. Retrieved February 13, 2017 . 
6. ^ Past Prizes. In: amacad.org. American Academy of Arts and Sciences , accessed September 10, 2019 . 
7. ^ William C. Rose Award. In: asbmb.org. Retrieved February 13, 2017 . 
8. ^ Henry Lardy. In: nasonline.org. Retrieved February 13, 2017 . 
9. ↑ Book of Members 1780 – present, Chapter L. (PDF; 1.1 MB) In: American Academy of Arts and Sciences (amacad.org). Retrieved September 10, 2019 . 
10. ^ American Philosophical Society - Member History. In: amphilsoc.org. Retrieved February 13, 2017 .