Indian Verma

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Inder M. Verma (born November 28, 1947 in Sangrur , Punjab ) is an Indian-American molecular biologist and molecular geneticist. He is known for research on cancer , immunology, and gene therapy .

Life

Verma studied at the University of Lucknow and received her doctorate from the Weizmann Institute in 1971 . As a post-doctoral student , he was with David Baltimore at the Massachusetts Institute of Technology . In 1974 he became assistant professor, 1979 associate professor and was professor at the Salk Institute for Biological Studies from 1985 to 2018 . He is also an Adjunct Professor at the University of California, San Diego , and on the Board of the Scripps Research Institute . He is the American Cancer Society Professor of Molecular Biology and holds the Irwin and Joan Jacobs Chair in Life Sciences.

His work on viruses and on carcinogenesis led to the discovery of oncogenes such as c-fos . He studied how genetic defects in development lead to cancer and, among other things, investigated the question of how inflammation can lead to cancer using the transcription factor NF-κB . He was a pioneer in the development of retrovirus- based techniques to incorporate genes into body cells ( transduction ). They are channeled back into the body for the purpose of gene therapy, for example, to produce proteins that are missing in the body. He also used and developed the method of induced pluripotent stem cells (iPSC). Among other things, his laboratory succeeded in developing iPSC for models of lung tissue.

In his laboratory, he showed that, contrary to popular belief, glioblastomas can arise from several types of nerve cells. Together with colleagues, he found that the breast cancer gene 1 ( BRCA1 ) also plays a role in gene regulation in the brain.

In 2010 he received the Pasarow Award for Cancer Research and in 2008 the Vilczek Prize in Biomedicine.

He is a member of the National Academy of Sciences , the American Academy of Arts and Sciences , the American Association for the Advancement of Science , the European Molecular Biology Organization (EMBO), the American Philosophical Society , the Indian National Science Academy, and the Third World Academy of Sciences .

Verma was editor of the Proceedings of the National Academy of Sciences (PNAS) from 2011 to 2018 .

Verma was accused in 2017 of actively hindering the promotion of women at the Salk Institute. In addition, there were subsequently allegations of sexual harassment against Verma, who has since resigned from his editorial work and his position at the Salk Institute Salk.

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Individual evidence

  1. ^ AD Miller, T. Curran, IM Verma: c-fos protein can induce cellular transformation: a novel mechanism of activation of a cellular oncogene. In: Cell . Volume 36, Number 1, January 1984, pp. 51-60, PMID 6607118 .
  2. ↑ D. Friedmann-Morvinski, IM Verma: Dedifferentiation and reprogramming: origins of cancer stem cells. In: EMBO reports. Volume 15, number 3, March 2014, pp. 244-253, doi : 10.1002 / embr.201338254 , PMID 24531722 , PMC 3989690 (free full text) (review).
  3. ↑ AL Firth, T. Menon et al. a .: Functional Gene Correction for Cystic Fibrosis in Lung Epithelial Cells Generated from Patient iPSCs. In: Cell reports. Volume 12, number 9, September 2015, pp. 1385-1390, doi : 10.1016 / j.celrep.2015.07.062 , PMID 26299960 , PMC 4559351 (free full text).
  4. ↑ D. Friedmann-Morvinski, EA Bushong et al. a .: Dedifferentiation of neurons and astrocytes by oncogenes can induce gliomas in mice. In: Science . Volume 338, number 6110, November 2012, pp. 1080-1084, doi : 10.1126 / science.1226929 , PMID 23087000 , PMC 3595315 (free full text).
  5. ↑ GM Pao, Q. Zhu et al. a .: Role of BRCA1 in brain development. In: Proceedings of the National Academy of Sciences . Volume 111, number 13, April 2014, pp. E1240 – E1248, doi : 10.1073 / pnas.1400783111 , PMID 24639535 , PMC 3977248 (free full text).
  6. ↑ Christine Mlot: Famed cancer biologist allegedly sexually harassed women for decades. In: sciencemag.org. May 23, 2018, accessed on September 22, 2018 .
  7. ^ Accused cancer scientist resigns as editor of prestigious journal. In: sciencemag.org. May 3, 2018, accessed on September 22, 2018 .
personal data
SURNAME Verma, Indian
ALTERNATIVE NAMES Verma, Indian M.
BRIEF DESCRIPTION Indian-American molecular biologist and molecular geneticist
DATE OF BIRTH November 28, 1947
PLACE OF BIRTH Sangrur , Punjab