Ingrid Herr

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Ingrid Herr (2011)

Ingrid Herr (* 1962 in Bretten ) is a German professor , biologist and scientist in the field of cancer research . Her scientific research topics focus in particular on the therapy resistance mechanisms of tumor stem cells . From 2005 to 2012 she was a professor at the University of Ulm , where she gave a “biochemistry internship on amino acid metabolism” until 2011. Since her rehabilitation in 2012, she has been teaching at the Medical Faculty in Heidelberg , where she holds, among other things, internships and seminars on the subject of “tumor stem cells of pancreatic carcinoma” and “animal experiment replacement model of pancreatic carcinoma”.

Life

Ingrid Herr first attended elementary school and grammar school from 1969 to 1982, completed a voluntary social year after graduating from high school and from 1983 to 1984 training as a commercial clerk in Bretten. She then studied biology at the University of Ulm from 1984 to 1990 and graduated with a diploma . The subject of her diploma thesis was the " Expression of p53 in a rabbit reticulocyte and a bacculovirus system." During this time she worked as a student assistant in the field of biochemistry internship for medical students and then supervised the series of experiments on the subject of "Glycogen in the rat liver." she went to the University of Karlsruhe to start her doctoral thesis at the research center there, at the Institute for Genetics and Toxicology. The main topics were the studies on the transcription control of the proto-oncogene c-jun . In 1995 she received her PhD in this field.

As part of her research, she received an extraordinary professorship at the University of Ulm in 2005 , in 2007 she was offered a professorship for adult stem cells at the Medical Faculty of the University of Göttingen and in 2012 she completed her habilitation at the Medical Faculty of the Ruprecht-Karls-Universität Heidelberg .

Scientific work

From 1995 onwards, Herr worked as a postdoctoral fellow at the German Cancer Research Center in the field of molecular oncology and pediatrics . There she worked closely with Klaus-Michael Debatin and Peter Krammer in the research of the connections between apoptosis mechanisms and the chemotherapy resistance of pediatric tumor diseases . Herr wrote several papers on this, which appeared in the journals Nature Medicine , The EMBO Journal and Blood , among others .

Ingrid Herr has been head of the clinical cooperation group “Molecular Onco-Surgery” at the Surgical University Clinic in Heidelberg and at the German Cancer Research Center since July 1, 2006 . Since November 2014 she has taken over the management of the "Surgical Research" section at the Heidelberg University Surgical Clinic. As part of her surgical research, she published in internationally renowned journals such as Lancet Oncology , Hepatology , Gut , Cancer Research , Clinical Cancer Research or the Journal of the National Cancer Institute . In 2012 she received the Sebastian Kneipp Prize, endowed with 10,000 euros, from the Kneipp Foundation for her extensive research on the influence of nutrients, such as those found in broccoli, on cancer. Current research deals with bioactive ingredients from fruits and vegetables and their regulatory mechanisms that inhibit the growth of pancreatic cancer.

Awards

  • 1997: Franziska Kolb Prize - Prize for Leukemia Research
  • 2007: Award for the best scientific work of the European Pancreas Club.
  • 2012: Sebastian Kneipp Prize from the Sebastian Kneipp Foundation, Bad Wörishofen .

Fonts (selection)

  • Mechanisms of transcription control of the proto-oncogene c-jun. (= Dissertation). Forschungszentrum Karlsruhe GmbH, Karlsruhe 1995, DNB 943865239 .
  • with Claudia Friesen et al .: Involvement of the CD95 (APO-1 / Fas) receptor / ligand system in drug-induced apoptosis of leukemia cells. In: Nature Medicine . No. 2, 1996, pp. 574-577.
  • Cellular Stress and the Induction of Apoptosis. (= Habilitation thesis). Ulm University, Ulm 2000, DNB 962295434 .
  • with other authors: Glucocorticoid co-treatment induces apoptosis resistance towards cancer therapy in carcinomas. In: Cancer Research . No. 63, 2003, pp. 3112-3120.
  • mit J. Pfitzenmaier: Glucocorticoid use in prostate cancer and other solid tumors: implications for effectiveness of cytotoxic treatment and metastases. In: Lancet Oncol. No. 7, 2006, pp. 425-426.
  • with P. Schemmer, MW Büchler: On the TRAIL to therapeutic intervention in liver disease. In: Hepatology. No. 46, 2007, pp. 266-274.
  • with G. Kallifatidis, V. Rausch, B. Baumann, A. Apel, et al .: Sulforaphane targets pancreatic tumor-initiating cells by NF-κB-induced anti-apoptotic signaling. In: GOOD. No. 58, 2009, pp. 949-963.
  • with V. Rausch, B. Baumann, et al .: Synergistic activity of sorafenib and sulforaphane abolishes pancreatic cancer stem cell characteristics. In: Cancer Research. No. 70, 2010, pp. 5004-5013.
  • with Klaus-Michael Debatin: Cellular stress response and apoptosis in cancer therapy. In: Blood . No. 98, 2011, pp. 2603-2614.
  • with other authors: New gene-immunotherapy combining TRAIL-lymphocytes and EpCAMxCD3 bispecific antibody for tumor targeting. In: Clin Cancer Research. No. 18, 2012, pp. 1028-1038.
  • with G.Moldenhauer, A. Salnikov, S. Lüttgai, J. Anderl, H. Faulstich: Therapeutic potential of amanitin-conjugated anti-epithelial cell adhesion molecule antibody against pancreatic carcinoma. In: Journal of the National Cancer Institute . No. 104, 2012, pp. 622-634.
  • mit, V. Rausch, MW Büchler: Mustard oil bomb of cruciferous vegetables - plant defense mechanism with therapeutic effect. In: German journal oncology. No. 45, 2013, pp. 4–13.

Web links

Individual evidence

  1. Cornelia Kästner: Ingrid Herr: With broccoli active ingredients against cancer ( Memento from April 10, 2013 in the Internet Archive ) on laborwelt.de.
  2. resume on klinikum.uni-heidelberg.de, accessed June 17, 2013.
  3. a b Ingrid Herr - detailed curriculum vitae ( memento from April 5, 2016 in the Internet Archive ) on biokrebs.de.
  4. ^ Heidelberg University Hospital: Head. Klinikum.uni-heidelberg.de, accessed on June 27, 2018 .
  5. Karen Hoffschulte: Broccoli active ingredients against cancer. In: Studies in a nutshell. carstens-stiftung.de, accessed on December 5, 2018 .