Iohexol

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Structural formula
Structural formula of iohexol
Mixture of diastereomers and atropisomers
General
Non-proprietary name Iohexol
other names

1- N , 3- N -bis (2,3-dihydroxypropyl) -5- [ N - (2,3-dihydroxypropyl) acetamido] -2,4,6-triiodobenzene-1,3-dicarboxamide

Molecular formula C 19 H 26 I 3 N 3 O 9
Brief description

white to off-white, hygroscopic powder

External identifiers / databases
CAS number 66108-95-0
EC number 266-164-2
ECHA InfoCard 100.060.130
PubChem 3730
ChemSpider 3599
DrugBank DB01362
Wikidata Q410683
Drug information
ATC code

V08 AB02

Drug class

Contrast media

properties
Molar mass 821.14 g · mol -1
solubility
safety instructions
Please note the exemption from the labeling requirement for drugs, medical devices, cosmetics, food and animal feed
GHS labeling of hazardous substances
no GHS pictograms
H and P phrases H: no H-phrases
P: no P-phrases
Toxicological data

> 20,000 mg kg −1 ( LD 50 ,  rat ,  oral )

As far as possible and customary, SI units are used. Unless otherwise noted, the data given apply to standard conditions .

Iohexol is a mixture of several isomeric chemical compounds that belong to the halogen aromatic compounds and polyols . It is very soluble in water and is used in medicine under the trade name Omnipaque ® as an iodine-containing contrast medium . When administered intravenously, iohexol is used to visualize blood vessels during x-ray examinations ( angiography ). Since the active substance is completely excreted via the kidneys , it is also suitable for excretory urography and for determining renal clearance .

Individual evidence

  1. ↑ a b c d e data sheet IOHEXOL CRS (PDF) at EDQM , accessed on September 21, 2009.
  2. ↑ a b Histodenz ™ data sheet , nonionic density gradient medium from Sigma-Aldrich , accessed on February 17, 2013 ( PDF ).