Iopamidol

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Structural formula
Structural formula of Iopamidol
General
Non-proprietary name Iopamidol
other names

1- N , 3- N -bis (1,3-dihydroxypropan-2-yl) -5 - [(2 S ) -2-hydroxypropanamido] -2,4,6-triiodobenzene-1,3-dicarboxamide

Molecular formula C 17 H 22 I 3 N 3 O 8
Brief description

white to almost white powder

External identifiers / databases
CAS number 60166-93-0
EC number 262-093-6
ECHA InfoCard 100.056.430
PubChem 65492
ChemSpider 58940
DrugBank DB08947
Wikidata Q424788
Drug information
ATC code

V08 AB04

Drug class

Contrast media

properties
Molar mass 777.08 g · mol -1
solubility

Easily soluble in water, very slightly soluble in methanol , practically insoluble in dichloromethane and ethanol

safety instructions
Please note the exemption from the labeling requirement for drugs, medical devices, cosmetics, food and animal feed
GHS labeling of hazardous substances
no GHS pictograms
H and P phrases H: no H-phrases
P: no P-phrases
Toxicological data

28,200 mg kg −1 ( LD 50 ,  rat ,  iv )

As far as possible and customary, SI units are used. Unless otherwise noted, the data given apply to standard conditions .

Iopamidol is an active ingredient that contains iodine and is used in medicine as a contrast medium . Administered intravenously, it is used to display blood vessels ( angiography ) during X-ray examinations . It was launched in 1977. Since the active substance is completely excreted via the kidneys , it is also suitable for excretory urography and for determining renal clearance . When administered intrathecally , iopamidol is also used for myelography and visualization of the cerebral ventricles .

The substance is found in surface waters, because sewage treatment plants cannot remove the substance well from the wastewater even with a fourth purification stage, with ozone or activated carbon. See also contrast media .

Trade names

Cetegnost, Iopamigita, Iopamiro, Iopamiron, Isovue, Niopam, Scanlux, Solutrast, Unilux

Individual evidence

  1. ↑ a b Data sheet IOPAMIDOL CRS (PDF) at EDQM , accessed on September 21, 2009.
  2. ↑ a b lgcstandards: MSDS ( Memento from August 12, 2014 in the Internet Archive ) (PDF; 173 kB).
  3. ↑ GWA Milne: Gardner's Commercially Important Chemicals: Synonyms, Trade Names, and ... John Wiley & Sons, 2005, ISBN 0-471-73661-9 , pp. 339 ( limited preview in Google Book search).
  4. ↑ Andreas Beck: Angiography of the hand diagnostics and therapy . Springer-Verlag, 2013, ISBN 978-3-642-78923-6 , pp. 44 ( limited preview in Google Book search).
  5. ^ Negotiation report of the German Society for Urology, 36th conference, October 3 to 6, 1984, Bremen . Springer-Verlag, 2013, ISBN 978-3-642-82538-5 , p. 540 ( limited preview in Google Book search).
  6. ↑ Peter Dawson, Wolfram Clauß: Contrast media in practice . Springer-Verlag, 2013, ISBN 978-3-642-93540-4 , pp. 30 ( limited preview in Google Book search).
  7. ^ H. Gänshirt, Peter Berlit, G. Haack: Cardiovascular diseases and nervous system neurotoxicology problems of brain death 58th conference. Annual conference from 19.-22. September 1984 in Heidelberg . Springer-Verlag, 2013, ISBN 978-3-642-46521-5 , pp. 511 ( limited preview in Google Book search).
  8. ↑ Abegglen C., Siegrist H: Micropollutants from municipal wastewater. Process for further elimination in sewage treatment plants. (PDF; 3.5 MB) In: Environmental Knowledge. Federal Office for the Environment, Bern, 2012 .;