Iprindole

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Structural formula
Structural formula of Iprindole
General
Non-proprietary name Iprindole
other names

3- (6,7,8,9,10,11-hexahydro-5 H -cycloocta [ b ] indol-5-yl) - N , N -dimethylpropan-1-amine

Molecular formula C 19 H 28 N 2
External identifiers / databases
CAS number
EC number 226-933-5
ECHA InfoCard 100.024.485
PubChem 21722
Wikidata Q904673
Drug information
ATC code

N06 AA13

Drug class

antidepressant

properties
Molar mass
  • 284.44 g mol −1 (iprindole)
  • 320.90 g mol −1 (Iprindole hydrochloride)
Physical state

firmly

Melting point

146–147 ° C (iprindole hydrochloride)

safety instructions
Please note the exemption from the labeling requirement for drugs, medical devices, cosmetics, food and animal feed
GHS hazard labeling
no classification available
As far as possible and customary, SI units are used. Unless otherwise noted, the data given apply to standard conditions .

Iprindol is a drug from the group of tricyclic antidepressants .

The indole derivative iprindole acts as a 5-HT 2 antagonist and indirect β 2 agonist . In addition, it has a weak anticholinergic and antihistaminic effect . It has no effect on the resumption of norepinephrine .

In terms of antidepressant effects, it is said to be just as effective as imipramine . In another study it was found that iprindole unlike other tricyclic antidepressants and MAOIs the REM sleep should not influence.

Individual evidence

  1. ^ The Merck Index : An Encyclopedia of Chemicals, Drugs, and Biologicals. 14th edition. Merck & Co., Whitehouse Station, NJ, USA, 2006, ISBN 0-911910-00-X , p. 883.
  2. ↑ This substance has either not yet been classified with regard to its hazardousness or a reliable and citable source has not yet been found.
  3. ↑ K. Rickels, HR Chung, I. Csanalosi, L. Sablosky, JH Simon: Iprindole and imipramine in non-psychotic depressed out-patients. In: Br. J. Psychiatry. Vol. 123, No. 574, 1973, pp. 329-339. PMID 4583430 doi: 10.1192 / bjp.123.3.329 .
  4. ↑ BL Baxter, MI Gluckman: Iprindole: an antidepressant which does not block REM sleep. In: Nature. Volume 223, No. 5207, 1969, pp. 750-752. PMID 4308422 doi: 10.1038 / 223750a0 .

literature

  • H. Ganry, M. Bourin: Iprindole: a functional link between serotonin and noradrenaline systems? In: L'Encéphale. Vol. 20, No. 1, 1994, pp. 7-11. PMID 8174513
  • H. Ganry, M. Bourin: Is iprindole an indirect betamimetic drug? In: Neuropsychobiology. Volume 20, No. 4, 1988, pp. 187-193. PMID 2908249