Ivan Đikić

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Ivan Đikić (born May 28, 1966 in Zagreb ) is a Croatian molecular biologist and director of the Institute for Biochemistry II at the Goethe University in Frankfurt am Main.

Life

After completing his medical degree at the University of Zagreb (1991, MD), he devoted himself to molecular biology research. In the laboratory of Joseph Schlessinger at the Medical Center of New York University , he completed his scientific doctorate (degree: PhD). In 1997 he returned to Europe, where he set up his first independent research group at the Ludwig Institute for Cancer Research in Uppsala (Sweden) before accepting a professorship for biochemistry at the Medical Faculty of the Goethe University Frankfurt in 2002 . Since 2009 he has been director of the Institute for Biochemistry II at the Goethe University Frankfurt, and from 2009 to 2013 he was also the founding director of the Buchmann Institute for Molecular Life Sciences (BMLS). Since 2002 he has been setting up a laboratory as an affiliated professor at the University of Split . In 2014 he was the Vallee Foundation Visiting Professor at Harvard University . On February 13, 2017 he announced his retirement from scientific work in Croatia. He protested against the fact that the Minister of Education and Science of Croatia Pavo Barišić could remain in office after a plagiarism was discovered while doing a scientific paper and was covered by Prime Minister Andrej Plenković .

Act

Ivan Dikic's early work in Joseph Schlessinger's laboratory at New York University helped to understand in detail the transmission of signals through tyrosine kinases. He recognized that modulating the signal strength significantly changes the cellular response to an external signal. He discovered that the small protein ubiquitin plays an essential role in intracellular signal processing. At that time, ubiquitin was known as a protein present in all cell types, which is covalently linked to other proteins and thus marks them for disposal in the cellular shredder, the proteasome. In 2004, Aaron Ciechanover , Avram Hershko and Irwin Rose were awarded the Nobel Prize in Chemistry for discovering the role of ubiquitin in protein degradation . Ivan Dikic was instrumental in elucidating further functions and mechanisms of this central post-translational modification system. His group identified several ubiquitin binding domains on proteins and together with Koraljka Husnjak he discovered a previously unknown ubiquitin receptor on the proteasome (RPn13), until now only the RPn10 receptor was known. He studies the role of ubiquitin in receptor-mediated endocytosis , in the immune system, in DNA repair and protein breakdown in proteasomes . The research has, among other things, applications in the elucidation of the molecular mechanisms of cancer development and provides points of attack for drug development.

In 2011, he and colleagues clarified the molecular mechanisms underlying the cellular response to Salmonella infections. Among other things, this triggers selective autophagocytosis , a signal path in which ubiquitin plays a central role. Ivan Dikic's group succeeded in identifying an autophagocytic receptor that regulates the elimination of ubiquitin-labeled salmonella. After penetrating cells in the intestinal wall, salmonella is provided with ubiquitin and thus marked for removal. As a result, the salmonellae are surrounded by special membrane vesicles, so-called autophagosomes, mediated by the autophagy receptor optineurin. The autophagosomes fuse with lysosomes and their contents are broken down by lysosomal enzymes. Dikic and colleagues found that phosphorylation of optineurin by the protein kinase TBK 1 is the crucial step in activating the receptor for the elimination of Salmonella. In order to gain a more comprehensive understanding of the molecular processes following a bacterial infection, the groups of Ivan Dikic and Christian Behrends determined the ubiquitination processes that the invasion of Salmonella causes in the host cell using quantitative mass spectrometry . In view of the increasing frequency of resistance, the findings can help in the development of new antibiotics against Salmonella and in understanding other autophagocytosis processes in the cell. Under the direction of Dikic, a special research area of ​​the German Research Foundation on autophagy (SFB 1177) was created in 2015 .

Awards and memberships (selection)

Web links

Individual evidence

  1. ↑ ibcii - Institute of Biochemistry II. In: www.biochem2.de. Retrieved October 14, 2016 .
  2. ^ Institute of Biochemistry II. In: www.biochem2.com. Retrieved October 14, 2016 .
  3. ↑ "Zbogom" Ivan Đikić eg of the abovementioned Andreja Plenkovića napušta Hrvatsku. On: index.hr , February 13, 2017
  4. ↑ DFG, research focus Ivan Dikic , Leibniz Prize 2013.
  5. ↑ Recognition of the Leibniz Prize
  6. ↑ K. Husnjak, S. Elsasser, N. Zhang, X. Chen, L. Randles, Y. Shi, K. Hofmann, KJ Walters, D. Finley, I. Dikic: Proteasome subunit Rpn13 is a novel ubiquitin receptor. In: Nature. Volume 453, number 7194, May 2008, pp. 481-488, doi: 10.1038 / nature06926 . PMID 18497817 , PMC 2839886 (free full text).
  7. ^ Professor Ivan Dikic solved "Nobel mystery". 2008, to the Nature article
  8. ↑ P. Wild, H. Farhan, DG McEwan, S. Wagner, VV Rogov, NR Brady, B. Richter, J. Korac, O. Waidmann, C. Choudhary, V. Dötsch, D. Bumann, I. Dikic: Phosphorylation of the autophagy receptor optineurin restricts Salmonella growth. In: Science. Volume 333, Number 6039, July 2011, pp. 228-233, doi: 10.1126 / science.1205405 . PMID 21617041 , PMC 3714538 (free full text).
  9. ↑ Intestinal cell defense mechanism against bacteria, EurekaAlert, 2011
  10. ^ Anne Hardy: SFB for selective autophagy approved. University of Frankfurt, November 25, 2015.
  11. ↑ Ernst Jung Prize for Medicine, Prize Winner 2013 ( Memento from March 10, 2013 in the Internet Archive ) at the Jung Foundation (jung-stiftung.de); Retrieved January 9, 2013.
  12. ↑ Ivan Dikic will receive the William C. Rose Award 2013 from Informationsdienst Wissenschaft (idw-online.de); Retrieved November 3, 2012.
  13. ↑ High-ranking research award for biochemists from Frankfurt. on: welt.de , December 6, 2012.
  14. ↑ Member entry by Prof. Dr. Ivan Dikic (with picture) at the German Academy of Sciences Leopoldina , accessed on July 4, 2016.
  15. ^ Information service science : Ivan Dikic receives AACR prize for outstanding achievements in cancer research.
personal data
SURNAME Đikić, Ivan
BRIEF DESCRIPTION Croatian biochemist and molecular biologist
DATE OF BIRTH May 28, 1966
PLACE OF BIRTH Zagreb