Aaron Ciechanover

Aaron Ciechanover (2004)

Aaron Judah Ciechanover ( Hebrew אהרון צ'חנובר; ) (Born October 1, 1947 in Haifa , Palestine ) is an Israeli biochemist . In 2004, together with Avram Hershko and Irwin Rose, he received the Nobel Prize in Chemistry for their discovery of ubiquitin- controlled protein degradation.

Life

He is the son of the English teacher and housewife Bluma Ciechanover geb. Lubashevsky and the clerk of a law firm and later attorney Yitzhak Ciechanover. His family emigrated from Poland to Palestine before World War II. Ciechanover studied medicine at the Hebrew University in Jerusalem (MD 1972 with Avram Hershko ) and then received his specialist training in Haifa ( Rambam Medical Center , 1972/73). He then worked for three years as a doctor in the Israeli army. From 1976 he was at the Technion (Israel Institute of Technology) in Haifa, where he received his doctorate (D. Sc.) In 1981 under Avram Hershko. As a post-doctoral student , he was at the Whitehead Institute for Biomedical Research at MIT with Harvey F. Lodish from 1981 to 1984 . Since 1984 he has been doing research at the Technion Medical Faculty, where he became a professor and is director of the Rappaport Family Institute for Research in Medical Sciences .

In the late 1970s and early 1980s, in collaboration with Hershko and Rose, he explained how cells destroy and reprocess excess proteins. The ubiquitin molecule attaches itself to the molecule to be destroyed, which is transported to the proteasome , where it is broken down into small peptides and amino acids. Only proteins marked with ubiquitin are broken down there and the ubiquitin is then used again. The breakdown of superfluous proteins is vital for the cell and a disruption of the process can lead to serious diseases. The ubiquitin-proteasome system (ubiquitin-proteasome system UPS) is also the starting point for chemotherapeutic agents against cancer (a first such drug was bortezomib , which was approved in the USA in 2003 ).

He is married to the doctor Menucha Ciechanover and has one son.

Further honors

• 2000: Albert Lasker Award for Basic Medical Research (together with Avram Hershko and Alexander Varshavsky )
• 2003: Israel Prize
• 2005: Member of the American Philosophical Society
• Honorary doctorates : 2001 Tel Aviv University , 2004 Ben Gurion University of the Negev in Beer Sheva , 2005 Osaka University , 2005 Athens University , 2006 Washington University in St. Louis , 2006 Universidad Peruana Cayetano Heredia in Lima , Peru , 2007 Hebrew University Jerusalem , 2007 Bar Ilan University , Ramat Gan, 2008 Universidad San Francisco de Quito , 2009 University of New South Wales , 2010 University of Haifa , 2011 University of Warsaw , Warsaw University of Technology , 2012 University of Łódź , Medical University of Łódź .
• 2008: Admission to the American Academy of Arts and Sciences as an honorary foreign member
• 2009: Centenary Prize of the Royal Society of Chemistry
• 2016: Member ( matriculation number 7686 ) of the Leopoldina

He is an external member of the National Academy of Sciences , a member of the Israeli Academy of Sciences , a full member of the Academia Europaea and a member of the Pontifical Academy of Sciences.

literature

• Aaron Ciechanover , in: Internationales Biographisches Archiv 01/2005 from January 8, 2005, in the Munzinger archive ( beginning of the article freely available)
• Leopoldina Newly Elected Members 2016, Leopoldina, Halle (Saale) 2017, p. 8 ( PDF )

Fonts

• with Y. Hod, A. Hershko: A Heat-stable Polypeptide Component of an ATP-dependent Proteolytic System from Reticulocytes, Biochem. Biophys. Res. Commun., Vol. 81, 1978, pp. 1100-1105.
• with H. Heller, S. Elias, AL Haas: ATP-dependent Conjugation of Reticulocyte Proteins with the Polypeptide Required for Protein Degradation, Proc. Natl. Acad. Sci. USA, Volume 77, 1980, pp. 1365-1368.
• with A. Hershko: Mechanisms of intracellular protein breakdown, Annu. Rev. Biochem., Vol. 51, 1982, pp. 335-364.

Web links

Commons : Aaron Ciechanover  - Collection of images, videos and audio files

• Information from the Nobel Foundation on the 2004 award ceremony for Aaron Ciechanover
• Curiosity, not the urge to save ( memento from September 6, 2009 in the Internet Archive ) In: Jüdische Zeitung , February 2007.
• Videos by and about Aaron Ciechanover in the AV portal of the Technical Information Library

Individual evidence

1. ↑ encyclopedia.jrank.org: Ciechanover, Aaron (1947-) - PERSONAL HISTORY, INFLUENCES AND CONTRIBUTIONS, BIOGRAPHICAL HIGHLIGHTS, PERSONAL CHRONOLOGY, THE WORLD'S PERSPECTIVE, LEGACY ( Memento of the original June 21, 2013 Internet Archive ) Info: The archive link was used automatically and not yet checked. Please check the original and archive link according to the instructions and then remove this notice. , accessed June 11, 2013. 
2. ↑ Aaron J. Ciechanover (PDF) vatican.va. Retrieved May 6, 2012.
3. ^ Member History: Aaron J. Ciechanover. American Philosophical Society, accessed June 19, 2018 . 
4. ^ Nobel Laureate receives Honorary Doctorate , January 16, 2009, University of New South Wales website
5. ^ University to award Prof. Aaron Ciechanover honorary doctorate . May 27, 2010. Archived from the original on November 5, 2011. Retrieved on April 5, 2019.
6. ↑ Book of Members 1780 – present, Chapter C. (PDF; 1.3 MB) In: American Academy of Arts and Sciences (amacad.org). Retrieved July 29, 2017 . 
7. ↑ Member entry by Prof. Dr. Aaron Ciechanover (with picture and CV) at the German Academy of Natural Scientists Leopoldina , accessed on January 4, 2017.
8. ↑ Directory of members: Aaron J. Ciechanover. Academia Europaea, accessed on July 29, 2017 .