Robert Lefkowitz

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Robert Lefkowitz

Robert Joseph Lefkowitz (born April 15, 1943 in New York City , New York ) is an American biochemist and professor at Duke University in Durham , North Carolina . In 2012 he and Brian Kobilka were awarded the Nobel Prize in Chemistry “for their studies on G-protein-coupled receptors ”.


Lefkowitz's parents Max and Rose Lefkowitz were descendants of Jewish emigrants who came to the United States from Poland in the late 19th century. In 1962 he earned a bachelor's degree in chemistry and an MD in 1966 , both from Columbia University in New York City . He then worked as an intern ( intern , later assistant resident ) at the Columbia-Presbyterian Medical Center , before moving to the National Institutes of Health in Bethesda , Maryland , as research assistant to Jesse Roth and Ira Pastan (* 1931) in 1968 . In 1970 he was hired as a senior resident at Massachusetts General Hospital in Boston , Massachusetts . Since 1973 Lefkowitz has held a professorship at Duke University Medical Center in Durham , North Carolina - initially as an assistant professor and since 1977 as a full professor. Since 1976 he has also been doing research work for the Howard Hughes Medical Institute in Durham.

Lefkowitz is married and has five children.


Lefkowitz was able to elucidate the structure, function and regulation of the beta-adrenoceptors as a model for the connection between G-protein-coupled receptors and cyclic AMP and at the same time the molecular mechanisms of the catecholamine effect. His work opened the field for research into various physiological and pathophysiological conditions and their drug treatment. More recent work deals with β-arrestins .

Awards (selection)


Web links

Commons : Robert Lefkowitz  - Collection of images, videos and audio files

Individual evidence

  1. ^ The Passano Awards 1945–2009 at; Retrieved April 16, 2011
  2. ^ Robert J. Lefkowitz, MD at; Retrieved October 10, 2012
  3. Book of Members 1780–2010 (PDF, 250 kB) at the American Academy of Arts and Sciences (; Retrieved April 17, 2011
  4. ^ Robert J. Lefkowitz at the National Science Foundation (; Retrieved April 16, 2011
  5. ^ Autobiography of Robert Lefkowitz at the Shaw Prize (; Retrieved April 16, 2011
  6. Pioneers of cell receptor research share America's top prize in medicine at; Retrieved April 17, 2011