Robert Lefkowitz
Robert Joseph Lefkowitz (born April 15, 1943 in New York City , New York ) is an American biochemist and professor at Duke University in Durham , North Carolina . In 2012 he and Brian Kobilka were awarded the Nobel Prize in Chemistry “for their studies on G-protein-coupled receptors ”.
Life
Lefkowitz's parents Max and Rose Lefkowitz were descendants of Jewish emigrants who came to the United States from Poland in the late 19th century. In 1962 he earned a bachelor's degree in chemistry and an MD in 1966 , both from Columbia University in New York City . He then worked as an intern ( intern , later assistant resident ) at the Columbia-Presbyterian Medical Center , before moving to the National Institutes of Health in Bethesda , Maryland , as research assistant to Jesse Roth and Ira Pastan (* 1931) in 1968 . In 1970 he was hired as a senior resident at Massachusetts General Hospital in Boston , Massachusetts . Since 1973 Lefkowitz has held a professorship at Duke University Medical Center in Durham , North Carolina - initially as an assistant professor and since 1977 as a full professor. Since 1976 he has also been doing research work for the Howard Hughes Medical Institute in Durham.
Lefkowitz is married and has five children.
Act
Lefkowitz was able to elucidate the structure, function and regulation of the beta-adrenoceptors as a model for the connection between G-protein-coupled receptors and cyclic AMP and at the same time the molecular mechanisms of the catecholamine effect. His work opened the field for research into various physiological and pathophysiological conditions and their drug treatment. More recent work deals with β-arrestins .
Awards (selection)
- 1978 Passano Young Scientist Award
- 1978 John J. Abel Award
- 1988 Gairdner Foundation International Award
- 1988 membership in the National Academy of Sciences
- 1988 membership in the American Academy of Arts and Sciences
- 2001 Jessie Stevenson Kovalenko Medal
- 2001 Pasarow Award
- 2001 Fred Conrad Koch Award
- 2003 Endocrine Regulation Prize
- 2006 George M. Kober Lectureship
- 2007 National Medal of Science
- 2007 Shaw Prize in Life Science and Medicine
- 2007 Albany Medical Center Prize
- 2009 BBVA Foundation Frontiers of Knowledge Award
- 2011 George M. Kober Medal
- 2012 Nobel Prize in Chemistry
literature
- Nicole Kresge, Robert D. Simoni and Robert L. Hill: Modeling β-Adrenergic Receptor Activation: the Work of Robert J. Lefkowitz. The Journal of Biological Chemistry , 282, e10 ( online )
- R. Snyderman: Introduction of Robert J. Lefkowitz. In: The Journal of clinical investigation. Volume 121, Number 10, October 2011, pp. 4192-4200, ISSN 1558-8238 . doi: 10.1172 / JCI60816 . PMID 21965339 . PMC 3195491 (free full text).
- Robert J. Lefkowitz , Internationales Biographisches Archiv 48/2012 from November 27, 2012, in the Munzinger archive ( beginning of article freely accessible)
Web links
- Information from the Nobel Foundation on the 2012 award ceremony for Robert Lefkowitz and Brian Kobilka
- Robert Lefkowitz 'laboratory (lefkolab.org)
- Robert J. Lefkowitz, MD and Research Abstract at the Howard Hughes Medical Institute (hhmi.org)
Individual evidence
- ^ The Passano Awards 1945–2009 at passanofoundation.org; Retrieved April 16, 2011
- ^ Robert J. Lefkowitz, MD at gairdner.org; Retrieved October 10, 2012
- ↑ Book of Members 1780–2010 (PDF, 250 kB) at the American Academy of Arts and Sciences (amacad.org); Retrieved April 17, 2011
- ^ Robert J. Lefkowitz at the National Science Foundation (nsf.gov); Retrieved April 16, 2011
- ^ Autobiography of Robert Lefkowitz at the Shaw Prize (shawprize.org); Retrieved April 16, 2011
- ↑ Pioneers of cell receptor research share America's top prize in medicine at amc.edu; Retrieved April 17, 2011
| personal data | |
|---|---|
| SURNAME | Lefkowitz, Robert |
| ALTERNATIVE NAMES | Lefkowitz, Robert Joseph; Lefkowitz Robert J .; Lefkowitz, Bob |
| BRIEF DESCRIPTION | American biochemist |
| DATE OF BIRTH | April 15, 1943 |
| PLACE OF BIRTH | New York City |