Jesse Roth

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Jesse Roth (born August 5, 1934 in New York City ) is an American endocrinologist .

Life

Roth earned a Masters in Art History from Columbia University in New York City in 1955 , but then studied medicine at Albert Einstein College , also in New York City, and graduated with an MD in 1959 . As a doctor, he worked at Barnes Hospital of Washington University School of Medicine in St. Louis , Missouri , before becoming a research fellow of the 1961 American Diabetes Association to Solomon Berson at the Veterans Administration Hospital went to New York City. Using a radioimmunoassay , Roth was able to measure growth hormone (GH) in blood samples for the first time and show its correlation with blood sugar levels .

In 1963, Roth moved to Jacob Robbins at the National Institute of Arthritis and Metabolic Diseases (now the National Institute of Diabetes and Digestive and Kidney Diseases , NIDDK), a facility of the National Institutes of Health (NIH) in Bethesda , Maryland , where he became head of the 1966 Department of Diabetes Research and later Scientific Director. In addition, from 1985 to 1991 he held the position of Assistant Surgeon General of the United States of the Public Health Service .

After nearly two decades at the NIDDK, Roth received a professorship in internal medicine at the Johns Hopkins University School of Medicine in Baltimore , Maryland, and became director of the department of geriatrics and gerontology there .

Since 2000, Roth has headed the diabetes research laboratory at the Feinstein Institute for Medical Research , which is part of the North Shore-Long Island Jewish Health System , a hospital association in New York State with around 44,000 employees, whose geriatric department is in Manhasset , New York between 2000 and 2006. In addition, Roth has professorships in internal medicine and molecular medicine at Hofstra University in Hempstead on Long Island , at the Albert Einstein College of Medicine in New York City and the small Elmezzi Graduate School of Molecular Medicine in Manhasset, New York, which he headed in 1998 / 1999 held.

Act

Together with Ira Pastan , Roth discovered that there are substances of various sizes that react with the antibodies against insulin , which correlated well with Donald F. Steiner's discovery of proinsulin . Roth and Pastan demonstrated that the ratio of insulin and proinsulin in the blood depends on certain physiological and pathophysiological conditions and that there are also precursors (such as proinsulin) for many other peptide hormones such as ACTH , gastrin , parathyroid hormone and growth hormone. Another field of research at that time was the hormone receptors for peptide hormones, in particular the TSH receptor and the ACTH receptor . Roth was able to show that the hormone-receptor binding is suitable as an in-vitro test for peptide hormones and that changes in the binding sites of the receptors can be responsible for hormone resistance and adaptation to hormone effects in humans. He also demonstrated receptors for insulin and growth hormone on white blood cells , which made it easier to study hormone receptors.

Current work deals with the metabolic syndrome and the early diagnosis of diabetes mellitus due to the increase in HbA1c 3 to 5 years and the C-peptide 5 to 10 years before the onset of diabetes. Another research focus is the microbiome , the totality of the microorganisms that colonize humans, and its importance for the metabolism and the development of obesity.

Awards (selection)

Web links

  • Jesse Roth, MD, FACP at the 3rd International Congress on Prediabetes and Metabolic Syndrome (kenes.com)
  • Jesse Roth, MD, FACP at the Feinstein Institute for Medical Research (feinsteininstitute.org)

Individual evidence

  1. ^ Ernst Oppenheimer Award - Endocrine Society. In: endocrine.org. December 31, 2013, accessed February 20, 2016 .
  2. ^ Presidential addresses of the American Society for Clinical Investigation (the-asci.org); Retrieved April 14, 2013
  3. ↑ Jesse Roth MD at the Gairdner Foundation (gairdner.org); Retrieved April 14, 2013
  4. ↑ Book of Members 1780 – present (PDF, 520 kB) at the American Academy of Arts and Sciences (amacad.org); Retrieved April 14, 2013
personal data
SURNAME Roth, Jesse
BRIEF DESCRIPTION American endocrinologist
DATE OF BIRTH August 5, 1934
PLACE OF BIRTH New York City