Richard F. Heck
Richard Fred Heck (born August 15, 1931 in Springfield , Massachusetts , † October 10, 2015 in Manila , Philippines ) was an American chemist who became known for the discovery of the Heck reaction . The reaction is used for the palladium- catalyzed linkage of aryl halides with alkenes and is one of the most important reactions for the formation of a carbon-carbon bond. In 2010 he received the Nobel Prize in Chemistry together with Ei-ichi Negishi and Akira Suzuki .
Scientific career
In 1952, Heck received his BS from the University of California (UCLA), Los Angeles . He remained there for at Saul Winstein with the work methoxy and aryl groups in substitution and rearrangement to a doctorate (1954). Then he went to Vladimir Prelog at the ETH Zurich . There he dealt with the solvolysis of cycloalkyl aryl sulfonates. Back at UCLA, he deepened his study of neighboring group effects . Then in 1956 he worked in the industry at Hercules Powder Co. in Wilmington (Delaware) . His research there on hydroformylation led to a first proposal for the mechanism of a transition-metal- catalyzed reaction.
In 1971 his path led him to the University of Delaware , where he continued to work on organopalladium chemistry. Here he discovered the Heck reaction, the importance of which can be read from the fact that in 2002 in Organic Reactions the chapter on the intramolecular Heck reaction alone comprised around 400 pages. He thus laid the foundation for a whole class of palladium-catalyzed reactions, including those involving derivatives of boronic acid , the Suzuki coupling and the Sonogashira coupling , which is used to couple fluorescent dyes to DNA . Heck also characterized the mechanism of alkene hydroformylation for the first time.
Heck retired in 1989 and lived in the Philippines , his wife's home , from 2011 until his death . There he mainly devoted himself to growing orchids .
Awards
In 2006 he received the Herbert C. Brown Award for Creative Research in Synthetic Methods. In addition, a chair was named in his honor in 2004. In 2010 he received the Nobel Prize in Chemistry together with Ei-ichi Negishi and Akira Suzuki . In 2011 he was awarded the Glenn T. Seaborg Medal .
Fonts (selection)
- RF Heck, JP Nolley, Jr .: Palladium-catalyzed vinylic hydrogen substitution reactions with aryl, benzyl, and styryl halides. In: Journal of Organic Chemistry . Volume 37, No. 14, 1972, pp. 2320-2322; doi : 10.1021 / jo00979a024 .
- RF Heck: Palladium Reagents in Organic Synthesis , Academic Press, New York 1985. XX, 461 pp., ISBN 0-12-336140-0 .
literature
- Ei-ichi Negishi : A profile of Professor Richard F. Heck Discovery of the Heck reaction . In: Journal of Organometallic Chemistry . Volume 576, 1999, pp. XV-XVI. doi : 10.1016 / S0022-328X (98) 01136-X .
- Victor Snieckus: Richard Heck (1931-2015). In: Nature . Volume 527, No. 7578, 2015, p. 306, doi: 10.1038 / 527306a
Web links
Individual evidence
- ^ Nobel laureate chemist Richard Heck, 84, this in Manila
- ↑ Life data, publications and academic family tree of Richard F. Heck at academictree.org, accessed on February 9, 2018.
- ↑ JT Link: The Intramolecular Heck Reaction. In: Organic Reactions. Volume 60, Wiley, Hoboken, New Jersey 2002, pp. 157-534.
- ↑ Linda Raber: Herbert C. Brown Award for Creative Research in Synthetic Methods . In: Chemical & Engineering News . Volume 84, No. 6, February 6, 2006, pp. 34-38.
- ↑ Information from the Nobel Foundation on the 2010 award ceremony to Richard F. Heck (English)
| personal data | |
|---|---|
| SURNAME | Heck, Richard F. |
| ALTERNATIVE NAMES | Heck, Richard Fred (full name) |
| BRIEF DESCRIPTION | American organic chemist, discoverer of the Heck reaction, Nobel laureate in chemistry 2010 |
| DATE OF BIRTH | August 15, 1931 |
| PLACE OF BIRTH | Springfield , Massachusetts |
| DATE OF DEATH | October 10, 2015 |
| Place of death | Manila , Philippines |