Arieh Warshel

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Arieh Warshel (2010)

Arieh Warshel (* 20th November 1940 in Sde Nahum , Israel ) is an Israeli - American chemist and university lecturer. On October 9, 2013, he was awarded the Nobel Prize for Chemistry together with Martin Karplus and Michael Levitt “for the development of multi-scale models for complex chemical systems” .

Education and research topics

Warshel was born in Kibbutz Sde-Nahum and studied after military service from 1958 to 1962 (most recently with the rank of captain ) from 1962 chemistry at the Technion in Haifa with a bachelor's degree in 1966 and a master's degree at the Weizmann Institute for Sciences in 1967. He received his doctorate in physical chemistry in 1969 from Shneior Lifson at the Weizmann Institute . As a post-doctoral student , he was at Harvard University from 1970 to 1972 . Then he worked again at the Weizmann Institute. 1974 to 1976 he was an EMBO fellow visiting scientist at the Laboratory of Molecular Biology in Cambridge . In 1976 he became an assistant professor at the University of Southern California , an associate professor in 1979 and a professor of chemistry in 1984. In 1991 he became Professor of Chemistry and Biochemistry and in 2011 Distinguished Professor .

Together with his colleagues, he developed processes and programs for computer simulation, particularly of protein functions and enzyme catalysis in biology. He worked with the co-recipient of the Nobel Prize Michael Levitt in the 1970s. He developed the Empirical Valence Bond Method (EVB) to describe chemical reactions in complex environments (solutions, polymers), with which he and his colleagues also succeeded in describing processes in enzyme catalysis that take place very quickly (in milliseconds).

From 1978 to 1980 he was a Sloan Research Fellow . In 2000 he became a fellow of the Biophysical Society, in 2008 of the Royal Society of Chemistry and in 2009 of the National Academy of Sciences . In 2003 he received the Tolman Award .

He has both Israeli and US citizenship. He has been married since 1966 and has two daughters.

Fonts

  • Computer Modeling of Chemical Reactions in Enzymes and Solution, Wiley 1991, 1997
  • with Jan Florián: The empirial valence bond (EVB) method , Encyclopedia of Computational Chemistry, Wiley 2004, doi: 10.1002 / 0470845015.cu0002
  • with Shina Kamerlin The empirical valence bond model: theory and applications , Computational Molecular Science, 1, 2011, 30–45, doi: 10.1002 / wcms.10

Web links

Commons : Arieh Warshel  - Collection of images, videos and audio files

Individual evidence

  1. AV Pisliakov, J. Cao, SCL Kamerlin, A. Warshel enzymes millisecond conformational dynamics do not catalyze the chemical step. In: Proceedings of the National Academy of Sciences . Volume 106, 2009, 17359-17364, doi: 10.1073 / pnas.0909150106 .