Jan Hoeijmakers

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Jan Hoeijmakers (1998)

Jan Hendrik Jozef Hoeijmakers (born March 15, 1951 in Sevenum ) is a Dutch molecular biologist, biochemist and molecular geneticist. He is known for elucidating the mechanisms of DNA repair and the effects of defects in the repair mechanism on gene stability in aging and cancer and various hereditary diseases.

Life

Hoeijmakers studied biology at Radboud University Nijmegen with a degree in 1975 (majoring in biochemistry and genetics) and received his doctorate in 1981 from the University of Amsterdam under Piet Borst ( Trypanosomes: Kinetoplast DNA and Antigenic Variation ). He then went to the Institute of Genetics at the Erasmus University Rotterdam to join Dirk Bootsma . In 1985 he received an assistant professorship there and a full professorship in 1993.

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In 1983 he was awarded the Harold Quintus Bosz Prize for his dissertation, in which he elucidated the molecular mechanism of antigen variation in trypanosomes . He uncovered the structure and main function of the mitochondrial DNA network of the parasite. He also clarified the complex genetic mechanism by which trypanosomes constantly change their surface antigens in order to escape the immune system.

In Rotterdam in the early 1980s he cloned the first human genes that were responsible for DNA repair and discovered a strong evolutionary stability of the DNA repair system. He clarified the mechanism of nucleotide excision repair (NER) and associated hereditary diseases ( Xeroderma pigmentosum , Cockayne syndrome , trichothiodystrophy ) and found J.-M. Egly that transcription factor IIH (TFIH) opens the DNA for the start of the NER. His laboratory was also involved in the precise elucidation of the factors involved in the repair of DNA and their regulation, developed mouse models and was able to observe DNA repair with fluorescence-labeled proteins in the living organism. In doing so, they also found a strong direct link between DNA repair and various signs of aging.

He holds several patents and is involved in founding the company Dnage (2004) in order to evaluate his own research results and those of his group. In 2011 he founded the company AgenD .

Awards

In 1998 he was awarded the Spinoza Prize , the highest Dutch science award , and in 1986 the Snoo van t'Hoogerhuys Prize (for isolating the first human gene for DNA repair). In 2000 he and colleagues received the Descartes Prize , the Van Gogh Prize in the same year, the Louis Jeantet Prize with Bootsma in 1995 for her work on DNA repair and others, the Josephine Nefkens Prize for cancer research in 2001 and in 2011 with Bert Vogelstein the Charles Rodolphe Brupbacher Prize for Cancer Research for research on genome stability and its role in aging and cancer. In 2011 he received the Queen Wilhelmina Research Award from the Dutch Society for Cancer Research and in 2008 an Advanced Grant from the European Research Council. In 2017 he received the International Prize of the Olav Thon Foundation .

In 2011 he became Academy Professor at the Royal Netherlands Academy of Sciences.

Fonts

  • JHJ Hoeijmakers: Genome maintenance mechanisms for preventing cancer. In: Nature . Volume 411, 2001, 366-374, doi: 10.1038 / 35077232 .
  • JH Hoeijmakers: DNA Damage, Aging, and Cancer. In: New England Journal of Medicine . Volume 361, 2009, pp. 1475-1485, doi: 10.1056 / NEJMra0804615 .
  • GA Garrinis, GT van der Horst, J. Vijg, JH Hoeijmakers: DNA damage and aging: new-age ideas for an age-old problem. In: Nature Cell Biology . Volume 10, 2008, pp. 1241-1247, doi: 10.1038 / ncb1108-1241 .
  • J. de Boer, JO Andressoo, J. de Wit, J. Huijmans, RB Beems, H. van Steeg, G. Weeda, GTJ van der Horst, W. van Leeuwen, APN Themmen, M. Meradji, JHJ Hoeijmakers: Premature aging in mice deficient in DNA repair and transcription. In: Science . Volume 296, 2002, pp. 1276-1279, doi: 10.1126 / science.1070174 .
  • LJ Niedernhofer, GA Garinis, A. Raams, SA Lalai, RA Robinson, E. Appeldoorn, H. Odijk, R. Oostendorp, A. Ahmad, W. van Leeuwen, A. Theil, W. Vermeulen, GT van der Horst, P. Meinecke, W. Kleijer, J. Vijg, NGJ Jaspers, JH Hoeijmakers: A new progeriod syndrome reveals that genotoxic stress suppresses the somatotroph axis. In: Nature. Volume 444, 2006, pp. 1038-1043, doi: 10.1038 / nature05456 .
  • H. Lans, JH Hoeijmakers: Cell Biology: Aging nucleus gets out of shape. In: Nature. Volume 440, 2006, pp. 32-34, doi: 10.1038 / 440032a .

Web links

personal data
SURNAME Hoeijmakers, Jan
ALTERNATIVE NAMES Hoeijmakers, Jan Hendrik Jozef; Hoeijmakers, Jan HJ
BRIEF DESCRIPTION Dutch molecular biologist
DATE OF BIRTH March 15, 1951
PLACE OF BIRTH Sevenum