Jan Huisken

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Jan Huisken

Jan Huisken (born November 26, 1974 in Göttingen ) is a German physicist . He has been Research Group Leader and Medical Engineering Director at the Morgridge Institute for Research at the University of Wisconsin at Madison since 2016 . Huisken is regarded as the founders of modern light sheet microscopy and was for his work with the medal for light microscopy 2017, the Royal Microscopical Society excellent (RMS).  

Life

Huisken studied physics at the Georg August University of Göttingen and the Ruprecht Karls University of Heidelberg . He was then a doctoral candidate in the international doctoral program of the European Molecular Biology Laboratory (EMBL) in Heidelberg . In the group of Ernst HK Stelzer, he conducted research on optical traps and high-resolution fluorescence microscopy from 2000 to 2004. The focus was his work on the multi-dimensional light sheet microscopy (Selective Plane Illumination Microscopy, SPIM) and its applications in the life sciences . Huisken completed this work with a doctorate at the Albert-Ludwigs-Universität Freiburg in 2004. As one of the first applications of light sheet microscopy, Huisken turned to the examination of Medaka embryos in Joachim Wittbrodt's laboratory. In 2005, Huisken moved to Didier Stainier's group at the University of California in San Francisco for a post-doctoral position . With the microscope he built himself, he researched cardiovascular morphogenesis and function in the zebrafish . Through this work he achieved a breakthrough as an international microscope developer today.

From 2010 to 2016, Huisken was an independent group leader at the Max Planck Institute for Molecular Cell Biology and Genetics in Dresden , Germany . In 2013 he also joined the Center for Systems Biology in Dresden. Since 2016 he has been group leader and director of the Medical Engineering department at the Morgridge Institute for Research in Madison at the University of Wisconsin in Madison.

Huisken is married and has two children.

Awards

literature

  • Brian Mattmiller: A novel data storage project unshackles microscopy from data overload. College of Engineering, UW-Madison, 19 Oct 2017.
  • Brian Mattmiller, Jan Huisken: Building a better, smarter microscope. Morgridge Institute for Research, News & Stories, 7 Mar 2017.
  • Brian Mattmiller: Focus on new faculty: Jan Huisken, developing new tools for biological imaging. College of Engineering, UW-Madison, News Details, Mar 12, 2016.
  • Brian Mattmiller: New Morgridge research team leader foresees era of 'smart microscopes'. Morgridge Institute for Research, News & Stories, 10 Mar 2016.
  • Heartbeat in 3D. Max Planck researchers observe zebrafish hearts at work. Max Planck Society, Newsroom, 22 Jul 2014.
  • Fundamentals of Embryo Development uncovered in real time. High-speed light sheet microscopy. Andor, Learning Academy.

Selected publications

  • Rory M Power, Jan Huisken: A guide to light-sheet fluorescence microscopy for multiscale imaging . In: Nature Methods . tape 14 , no. 4 , April 2017, ISSN  1548-7091 , p. 360–373 , doi : 10.1038 / nmeth.4224 ( nature.com [accessed May 30, 2018]).
  • Wiebke Jahr, Benjamin Schmid, Christopher Schmied, Florian O. Fahrbach, Jan Huisken: Hyperspectral light sheet microscopy . In: Nature Communications . tape 6 , no. 1 , September 2, 2015, ISSN  2041-1723 , doi : 10.1038 / ncomms8990 ( nature.com [accessed May 30, 2018]).
  • Nico Scherf, Jan Huisken: The smart and gentle microscope . In: Nature Biotechnology . tape 33 , no. 8 , August 2015, ISSN  1087-0156 , p. 815–818 , doi : 10.1038 / nbt.3310 ( nature.com [accessed May 30, 2018]).
  • Andrea Bassi, Benjamin Schmid, Jan Huisken: Optical tomography complements light sheet microscopy for in toto imaging of zebrafish development . In: Development . tape 142 , no. 5 , March 1, 2015, ISSN  0950-1991 , p. 1016-1020 , doi : 10.1242 / dev.116970 , PMID 25655702 ( biologists.org [accessed May 30, 2018]).
  • Michaela Mickoleit, Benjamin Schmid, Michael Weber, Florian O Fahrbach, Sonja Hombach, Jan Huisken: High-resolution reconstruction of the beating zebrafish heart . In: Nature Methods . tape 11 , no. 9 , July 20, 2014, ISSN  1548-7091 , p. 919–922 , doi : 10.1038 / nmeth.3037 ( nature.com [accessed May 30, 2018]).
  • Benjamin Schmid, Gopi Shah, Nico Scherf, Michael Weber, Konstantin Thierbach, Jan Huisken: High-speed panoramic light-sheet microscopy reveals global endodermal cell dynamics . In: Nature Communications . tape 4 , no. 1 , July 25, 2013, ISSN  2041-1723 , doi : 10.1038 / ncomms3207 ( nature.com [accessed May 30, 2018]).
  • Anna Kaufmann, Michaela Mickoleit, Michael Weber, Jan Huisken: Multilayer mounting enables long-term imaging of zebrafish development in a light sheet microscope . In: Development . tape 139 , no. 17 , September 1, 2012, ISSN  0950-1991 , p. 3242-3247 , doi : 10.1242 / dev.082586 , PMID 22872089 ( biologists.org [accessed May 30, 2018]).
  • Aristides B. Arrenberg, Didier YR Stainier, Herwig Baier, Jan Huisken: Optogenetic Control of Cardiac Function . In: Science . tape 330 , no. 6006 , November 12, 2010, ISSN  0036-8075 , p. 971–974 , doi : 10.1126 / science.1195929 , PMID 21071670 ( sciencemag.org [accessed May 30, 2018]).
  • Shane P. Herbert, Jan Huisken, Tyson N. Kim, Morri E. Feldman, Benjamin T. Houseman: Arterial-Venous Segregation by Selective Cell Sprouting: An Alternative Mode of Blood Vessel Formation . In: Science . tape 326 , no. 5950 , October 9, 2009, ISSN  0036-8075 , p. 294–298 , doi : 10.1126 / science.1178577 , PMID 19815777 ( sciencemag.org [accessed May 30, 2018]).
  • Jan Huisken, Didier YR Stainier: Selective plane illumination microscopy techniques in developmental biology . In: Development . tape 136 , no. 12 , June 15, 2009, ISSN  0950-1991 , p. 1963–1975 , doi : 10.1242 / dev.022426 , PMID 19465594 ( biologists.org [accessed May 30, 2018]).
  • Jan Huisken, Didier YR Stainier: Even fluorescence excitation by multidirectional selective plane illumination microscopy (mSPIM) . In: Optics Letters . tape 32 , no. 17 , September 1, 2007, ISSN  1539-4794 , p. 2608–2610 , doi : 10.1364 / OL.32.002608 ( osapublishing.org [accessed May 30, 2018]).
  • Jan Huisken, Jim Swoger, Filippo Del Bene, Joachim Wittbrodt, Ernst HK Stelzer: Optical Sectioning Deep Inside Live Embryos by Selective Plane Illumination Microscopy . In: Science . tape 305 , no. 5686 , August 13, 2004, ISSN  0036-8075 , p. 1007–1009 , doi : 10.1126 / science.1100035 , PMID 15310904 ( sciencemag.org [accessed May 30, 2018]).

Individual evidence

  1. ^ Mel: Medal Series. Retrieved May 30, 2018 .
  2. ↑ Jan Huisken, Jim Swoger, Filippo Del Bene, Joachim Wittbrodt, Ernst HK Stelzer: Optical Sectioning Deep Inside Live Embryos by Selective Plane Illumination Microscopy . In: Science . tape 305 , no. 5686 , August 13, 2004, ISSN  0036-8075 , p. 1007–1009 , doi : 10.1126 / science.1100035 , PMID 15310904 ( sciencemag.org [accessed May 30, 2018]).
  3. ↑ Jan Huisken, Didier YR Stainier: Even fluorescence excitation by multidirectional selective plane illumination microscopy (mSPIM) . In: Optics Letters . tape 32 , no. 17 , September 1, 2007, ISSN  1539-4794 , p. 2608–2610 , doi : 10.1364 / OL.32.002608 ( osapublishing.org [accessed May 30, 2018]).
  4. ^ Mel: Medal Series. Retrieved May 30, 2018 .
  5. ↑ ERC FUNDED PROJECTS . In: ERC: European Research Council . ( europa.eu [accessed May 30, 2018]).
  6. ↑ Super User: Twenty-seven researchers named as EMBO Young Investigators . In: EMBO . ( embo.org [accessed May 30, 2018]).
  7. ^ A novel data storage project unshackles microscopy from data overload - College of Engineering - University of Wisconsin-Madison . In: College of Engineering - University of Wisconsin-Madison . October 19, 2017 ( wisc.edu [accessed May 30, 2018]).
  8. ^ Jan Huisken: Building a better, smarter microscope . ( morgridge.org [accessed May 30, 2018]).
  9. ^ Focus on new faculty: Jan Huisken, developing new tools for biological imaging - College of Engineering - University of Wisconsin-Madison . In: College of Engineering - University of Wisconsin-Madison . March 12, 2016 ( wisc.edu [accessed May 30, 2018]).
  10. ↑ New Morgridge research team leader foresees era of 'smart microscopes' . ( morgridge.org [accessed May 30, 2018]).
  11. ↑ Heartbeat in 3D. Retrieved May 30, 2018 .
  12. ^ Andor: Jan Huisken Uses SPIM To Uncover Embryo Development | Andor. Retrieved May 30, 2018 (UK English).
personal data
SURNAME Huisken, Jan
BRIEF DESCRIPTION German physicist
DATE OF BIRTH November 26, 1974
PLACE OF BIRTH Goettingen