Jeffrey A. Bluestone

from Wikipedia, the free encyclopedia

Jeffrey Allen Bluestone (born April 8, 1953 in Fort Sill , Oklahoma ) is an immunologist and diabetes researcher at the University of California, San Francisco .

Live and act

Bluestone acquired in 1974 at Cook College of Rutgers University a Bachelor in Biology in 1977 at Rutgers University a Masters in Microbiology . In 1980 he received a Ph.D. from Cornell University. in immunology . From 1982 to 1987 he worked as a research group leader in the field of transplant biology at the National Cancer Institute . In 1987 he received his first professorship (associate professor) and in 1991 a full professorship at the University of Chicago , where he headed the Ben May Institute for Cancer Research from 1995 before he was appointed to a professorship at the University of California in 2000 , San Francisco (UCSF) and took over the management of the Diabetes Center at the Institute for Hormone Research . From 2010 to 2015 he was Vice Chancellor and Provost of the UCSF, and since 2010 he has been the overall director of the Institute for Hormone Research.

His research deals with the processes that underlie T-cell activation, in particular with understanding and influencing signals emanating from autoantigen- specific T cells and secondary, co-stimulatory signals. Bluestone is also investigating inhibitory effects on T cell activation. He was able to develop soluble receptor antagonists , monoclonal antibodies and certain experimental animals, each lacking a certain element of metabolic processes, thus defining the role of these elements in transplant rejection and autoimmunity . In particular, Bluestone explores regulatory T cells and their role in immune imbalance. Further work deals with immune tolerance in type I diabetes mellitus and with islet cell transplants .

In 2006 Bluestone was elected a member of the American Academy of Arts and Sciences .

Since 2016 Thomson Reuters has counted him among the favorites for a Nobel Prize ( Thomson Reuters Citation Laureates ) due to the number of his citations .

Web links

Individual evidence

  1. ↑ Dates of birth according to American Men and Women of Science , Thomson Gale 2004
  2. Book of Members 1780 – present (PDF, 1.0 MB) at the American Academy of Arts and Sciences (amacad.org); accessed on June 21, 2016.
  3. Web of Science Predicts 2016 Nobel Prize Winners. (No longer available online.) In: ipscience.thomsonreuters.com. September 21, 2016, archived from the original on September 21, 2016 ; accessed on September 21, 2016 (English).