Jorge Galán

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Jorge Enrique Galán (born October 19, 1956 in Pellegrini, Buenos Aires ) is a doctor from Argentina who teaches at Yale University and deals with the pathogenic effects of salmonella in particular .

Galan received his PhD in Veterinary Medicine from the National University of La Plata in 1980. In 1981 he went to the USA and received his doctorate from Cornell University in 1986 ( Studies on the immune response of the horse to the M protein of Streptococcus equi ). He is Professor of Cell Biology and Microbiological Pathogenesis at the Boyer Center for Molecular Medicine at Yale University Medical School ( Lucille P. Markey Professor of Microbial Pathogenesis ).

In 2011 he received the Robert Koch Prize for his research into the molecular mechanisms of the pathogenicity of certain bacteria, in particular Salmonella and Campylobacter , the biochemical interplay between host cells and pathogens and the changes that the bacterium triggers in the host cell (in the case of Salmonella for Example of the dissolution of the actin skeleton of the microvilli ). In the case of Salmonella, he showed how the bacterium uses a kind of molecular syringe (type III secretion apparatus) with which it injects a finely tuned sequence of proteins into the epithelial cells of the intestine. The type III secretion system arose from the flagellum system and also exists in other bacteria. Galan has been dealing with salmonella since the early 1990s. In 1992 he discovered at the State University of New York at Stony Brook that they dock to the EGF receptors in order to penetrate the cell .

In 2002, Galán received the Hans Sigrist Prize from the University of Bern , in 2009 he was elected a member of the German Academy of Natural Scientists Leopoldina , in 2012 a member of the National Academy of Sciences , and in 2019 a member of the National Academy of Medicine .

Web links

Individual evidence

  1. ↑ Spanish biography in Camera de diputados de Buenos Aires, Periodo 139, Asuntos Entrados, 2011, pdf ( Memento of the original from January 11, 2014 in the Internet Archive ) Info: The archive link was inserted automatically and has not yet been checked. Please check the original and archive link according to the instructions and then remove this notice. @1@ 2Template: Webachiv / IABot / www.hcdiputados-ba.gov.ar
  2. ↑ Galán, JB Bliska: Cross-talk between bacterial pathogens and their host cells , Ann. Rev. Cell. Dev. Bio., Vol. 12, 1996, pp. 221-255
  3. ↑ Tomoko Kubori, Matsushima, Nakamura, Uralil, Lara-Tejero, Sukhan, Galan, Aizawa: Supramolecular structure of the Salmonella typhimurium type III protein secretion system , Science, Volume 280, 1998, p. 602, Maria Lara-Tejero, Junya Kato , Samuel Wagner, Xiaoyun Liu, Jorge Galan: A Sorting Platform Determines the Order of Protein Secretion in Bacterial Type III Systems , Science, March 4, 2011, p. 1188
  4. ↑ Galan, Collmer: Type III secretion machines: bacterial devices for protein delivery into host cells , Science, Volume 284, 1999, p. 1322
  5. ↑ Galán, J. Pace, MJ Hayman: Involvement of the epidermal growth factor receptor in the invasion of cultured epithelial cells by Salmonella typhimurium , Nature, Volume 357, 1992, p. 588, Stroh, Exposing salmonella's gutsy moves - bacteria use complicated devices to invade cells , Science News 1992 ( Memento from July 8, 2012 in the web archive archive.today )
  6. ↑ Member entry by Prof. Dr. Jorge E. Galán (with picture) at the German Academy of Sciences Leopoldina , accessed on February 21, 2016.
personal data
SURNAME Galan, Jorge
ALTERNATIVE NAMES Galán, Jorge Enrique (full name)
BRIEF DESCRIPTION Argentine microbiologist
DATE OF BIRTH October 19, 1956
PLACE OF BIRTH Buenos Aires