Joseph Takahashi

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Joseph S. Takahashi (born December 16, 1951 in Tokyo ) is a Japanese-American neuroscientist who studies circadian rhythms .

Takahashi attended high school in Rockville, Maryland with a degree in 1970 and studied biology at Swarthmore College with a bachelor's degree in 1974. He then continued his studies with Michael Menaker at the University of Texas at Austin , followed Menaker to the University of Oregon , where he received his PhD in 1981. As a post-doctoral student , he worked with Martin Zatz at the National Institute of Mental Health until 1983 . He then went to Northwestern University , where he became a professor. In 1983 he became a research fellow of the Alfred P. Sloan Foundation ( Sloan Research Fellow ). In 2008 he became Professor at the University of Texas Southwestern Medical Center in Dallas ( Lloyd B. Sands Distinguished Chair in Neuroscience ). He is also a researcher at the Howard Hughes Medical Institute .

He deals with the internal clock in mammals (mouse, human). In 1994 he and his team discovered the clock gene and cloned it in 1997. He also investigated disorders of the internal clock and worked with the pharmaceutical company Hypnion.

He became a member of the National Academy of Sciences in 2003, the National Academy of Medicine in 2014 and the American Academy of Arts and Sciences in 2000 . In 2001 he received the W. Alden Spencer Award . In 2019 he received the Gruber Prize for Neuroscience .

Fonts (selection)

In addition to the works cited in the footnotes:

  • with Martin Zatz: Regulation of circadian rhythmicity, Science, Volume 217, 1982, pp. 1104-1111
  • with N. Gekakis u. a .: Role of the CLOCK Protein in the Mammalian Circadian Mechanism, Science, Volume 280, 1998, pp. 1564-1569, PMID 9616112
  • as editor with FW Turek, RY Moore: Handbook of Behavioral Neurobiology: Volume 12 Circadian Clocks, Kluwer 2001
  • with FW Turek u. a .: Obesity and Metabolic Syndrome in Circadian Clock Mutant Mice, Science, Volume 308, 2005, pp. 1043-1045. PMID 15845877
  • with KM Ramsey u. a .: Circadian Clock Feedback Cycle Through NAMPT-Mediated NAD + Biosynthesis, Science, Volume 324, 2009, pp. 651-654
  • with J. Bass: Circadian integration of metabolism and energetics, Science, Volume 330, 2010, pp. 1349-1354

Web links

Individual evidence

  1. ↑ MH Vita Terna, JS Takahashi u. a .: Mutagenesis and mapping of a mouse gene, Clock, essential for circadian behavior, Science, Volume 264, 1994, pp. 719-725. PMID 8171325
  2. ↑ David King, JS Takahashi et al. a .: Positional Cloning of the Mouse Circadian Clock Gene, Cell, Vol. 89, 1997, pp. 641-653. PMID 9160755
personal data
SURNAME Takahashi, Joseph
ALTERNATIVE NAMES Takahashi, Joseph S.
BRIEF DESCRIPTION Japanese neurobiologist
DATE OF BIRTH December 16, 1951
PLACE OF BIRTH Tokyo