Kainic acid

Structural formula
General
Surname	Kainic acid
other names	2-carboxy-3-carboxymethyl-4-isopropenyl-pyrrolidine (2 S , 3 S , 4 S ) -3- (carboxymethyl) -4-prop-1-en-2-ylpyrrolidine-2-carboxy acid
Molecular formula	C 10 H 15 NO 4
External identifiers / databases
CAS number 487-79-6 58002-62-3 (monohydrate) PubChem 10255 ChemSpider 9837 Wikidata Q390239
properties
Molar mass	213.2 g · mol -1
Physical state	firmly
Melting point	253–254 ° C (decomposition)
solubility	good in water
safety instructions
GHS labeling of hazardous substances Monohydrate no GHS pictograms H and P phrases H: no H-phrases P: no P-phrases
As far as possible and customary, SI units are used. Unless otherwise noted, the data given apply to standard conditions .

The kainic acid ( english kainic acid ) refers to a vegetable structural analogue of glutamic acid , which like these strong excitatory effect and excitotoxicity ( convulsions and degeneration of nerve cells leads).

Due to their agonistic effect on a subtype of the ionotropic glutamate receptors , these were named kainate receptors.

The kainic acid is used experimentally as a so-called chemical lesion tool to switch off nerve cells while protecting nerve fibers that run through the respective region.

See also

• Glutamate receptor

Individual evidence

1. ↑ Entry on domoic acid. In: Römpp Online . Georg Thieme Verlag, accessed on September 30, 2014.
2. ↑ ^{a b} Kainic acid monohydrate data sheet from Sigma-Aldrich , accessed on May 26, 2011 ( PDF ).
3. ^ Georg Löffler, Petro E. Petrides, Peter C. Heinrich: Biochemistry & Pathobiochemistry . Springer Medicine, Heidelberg 2006, ISBN 978-3-540-32680-9 , p. 1038 .