Copexile

from Wikipedia, the free encyclopedia
Structural formula
Structure of copexile
One of the two tautomers of Kopexil, 2,3-dihydro-3-hydroxy-2-imino-4-pyrimidinamine
General
Surname Copexile
other names
  • 2,3-dihydro-3-hydroxy-2-imino-4-pyrimidinamine
  • 2,4-diaminopyrimidine-3-oxide
  • DIAMINOPYRIMIDINE OXIDE ( INCI )
  • Aminexile
Molecular formula C 4 H 6 N 4 O
Brief description

white, odorless crystals

External identifiers / databases
CAS number
  • 113275-13-1
  • 74638-76-9
Wikidata Q782448
properties
Molar mass 126.1 g mol −1
Physical state

firmly

Melting point

210-218 ° C

solubility

slightly soluble in water

safety instructions
GHS hazard labeling
no classification available
As far as possible and customary, SI units are used. Unless otherwise noted, the data given apply to standard conditions .

Kopexil (brand name Aminexil ) is a synthetic chemical compound that the pyrimidine - and guanidine - derivatives counts. Kopexil is the parent compound of minoxidil , a drug used to treat high blood pressure and hereditary hair loss.

Chemical structure

Chemically, Kopexil is one of the N -oxides , a group of substances that has an oxo function as the fourth residue on the nitrogen atom of a tertiary amine, i.e. is oxidized . Since the nitrogen atom of the copexile also belongs to an amidine partial structure , two tautomeric structures of the compound can be formulated.

Tautomerism of Kopexil: 2,3-dihydro-3-hydroxy-2-imino-4-pyrimidinamine (left), 2,4-diaminopyrimidine-3-oxide (right)

Mechanism of action

To date, there are only speculations about the exact mechanism of action of Kopexil. Furthermore, the effectiveness against hair loss has not been proven.

Use in hair cosmetics

Kopexil is used locally - mostly in conjunction with minoxidil and retinol - to counteract hair loss due to premature exhaustion of the hair roots and thus enable better anchoring of the hair in the scalp . The concentration of copexile for this is z. B. 1.5%.

Individual evidence

  1. ↑ Entry on DIAMINOPYRIMIDINE OXIDE in the CosIng database of the EU Commission, accessed on December 28, 2019.
  2. ↑ a b c Kumar Organics: Kopexil . ( Memento of the original from July 22, 2015 in the Internet Archive ) Info: The archive link was automatically inserted and not yet checked. Please check the original and archive link according to the instructions and then remove this notice. (PDF; 524 kB) Retrieved March 28, 2012. @1@ 2Template: Webachiv / IABot / www.kumarorganic.net
  3. ↑ This substance has either not yet been classified with regard to its hazardousness or a reliable and citable source has not yet been found.
  4. ↑ a b Wolfgang Raab: Hair diseases in dermatological practice. Gabler Wissenschaftsverlage, 2012, ISBN 978-3-6422-0527-9 , p. 82. ( limited preview in Google book search).