Matthias Hentze

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Matthias Hentze

Matthias Werner Hentze (born January 25, 1960 in Wiedenbrück, today Rheda-Wiedenbrück ) is a German scientist and doctor. He is currently Director of the European Molecular Biology Laboratory (EMBL) and Professor of Molecular Medicine at Heidelberg University .

Life

In 1978, Hentze passed the Abitur examination at the Ratsgymnasium in Rheda-Wiedenbrück and then studied human medicine at the Westphalian Wilhelms University in Münster , as well as at the medical universities of Southampton, Oxford, Glasgow and Cambridge in the United Kingdom. In 1984 he obtained his license to practice medicine and obtained a doctorate in medicine. med. at the University of Münster on biogenesis, maturation and the transport of lysosomal enzymes with Kurt von Figura . Funded by a postdoctoral fellowship from the German Research Foundation (DFG), Hentze joined Richard D. Klausner's research group at the National Institutes of Health ( Bethesda , Maryland , USA ) in 1985 after a brief medical career . In 1989 Hentze moved to the European Molecular Biology Laboratory in Heidelberg as a scientific group leader . At the age of 30 he completed his habilitation in 1990 at the Ruprecht-Karls-Universität Heidelberg and was appointed Dean of the EMBL International PhD Program in 1996.

Together with Andreas Kulozik from the Medical Faculty of Heidelberg University, he founded the Molecular Medicine Partnership Unit (MMPU) in 2002 and is its co-director. The MMPU is the first institutional partnership between EMBL and a national research institution and is dedicated to interdisciplinary research at the interface between molecular biology and clinical medicine.

In 2005, Hentze was appointed Vice Director of EMBL and Professor of Molecular Medicine at Heidelberg University. He has been director of EMBL since June 2013 and advises and supports the director general Prof. Edith Heard.

Hentze is married and has three daughters. He regularly participates in the marathons of the World Marathon Majors series.

Act

Hentze's research is devoted to RNA biology and RNA-binding proteins. In 1987, Hentze and colleagues discovered the iron-responsive elements (IRE), the first example of an RNA element for translational gene regulation in mammals.

Hentze's research team has carried out fundamental work on understanding translation control (RNA-binding proteins, microRNAs ), the importance of which is now widely recognized for developmental biology , brain function, cancer development and other diseases. He also made key discoveries in the field of iron metabolism and its diseases. As part of the MMPU, he investigates diseases of the RNA metabolism, especially the so-called nonsense-mediated decay (NMD) and the 3'-end formation of mRNAs .

In 2010, Hentze proposed a new connection axis between metabolism and gene expression based on RNA-binding enzymes with the concept of REM Networks (Hentze and Preiss, 2010). The research project was funded with an ERC Advanced Investigator Grant from the European Research Council in 2011 . This work led to the development of the "RNA Interactome Capture" technique and the discovery of hundreds of new RNA-binding proteins in the cells of mammals and yeast, including over 50 metabolic enzymes. In 2016, Hentze and colleagues described novel RNA-binding motifs of proteins that they discovered with the help of the RBDmap method they developed. In 2019 they described the concept of riboregulation. They discovered that the autophagy receptor protein p62 is controlled by the direct attachment of a small RNA.

Awards and prizes (selection)

Hentze is a member of various national and international scientific societies such as the RNA Society, the BioIron Society (which he co-founded) and the German Society for Biochemistry and Molecular Biology (GBM).

Editorial boards

Hentze currently serves on the editorial boards of international journals, including Molecular Cell , RNA , EMBO Molecular Medicine , Trends in Biochemical Sciences , Journal of Molecular Medicine , BMC Molecular Biology , and Wiley Interdisciplinary Reviews: RNA .

Other activities

Hentze is or was a member of numerous international advisory bodies, including the scientific committee and board of trustees of the Max Delbrück Center for Molecular Medicine ( Berlin , Germany ), the scientific advisory committee of the Berlin Institute of Health (BIH / BIG) , the Istituto Nazionale Genetica Molecolare ( INGM) ( Milan , Italy ), the Centenary Institute ( Sydney , Australia ) and the Cold Spring Harbor Conferences Asia. Hentze is also the scientific co-founder of Anadys Pharmaceuticals ( San Diego , USA).

Publications

Hentze is a co-author of textbooks in the field of molecular medicine and has published over 250 original scientific articles.

Web links

Individual evidence

  1. ↑ a b EMBL Leadership
  2. ↑ Faculty at Heidelberg University Hospital
  3. ↑ a b c d e f Leopoldina CV.
  4. ↑ Heidelberg University Hospital. Prof. Dr. med. Andreas Kulozik. Retrieved August 5, 2015
  5. ↑ a b EMBL homepage. Molecular Medicine Partnership Unit. Retrieved May 11, 2020
  6. ↑ Press Release. "New research unit in the University Children's Hospital / EMBL." Retrieved April 3, 2020
  7. ↑ Abbott World Marathon Majors Six Star Finishers Hall of Fame. Accessed March 31, 2020.
  8. ↑ MW Hentze, SW Caughman, TA Rouault, JG Barriocanal, A Dancis, JB Harford, RD Klausner: Identification of the iron-responsive element for the translational regulation of human ferritin mRNA . In: Science . 238, No. 4833, December 1987, pp. 1570-73. doi : 10.1126 / science.3685996 . PMID 3685996 .
  9. ↑ N Sonenberg, A Hinnebusch: New modes of translational control in development, behavior, and disease . In: Mol Cell . 28, No. 5, December 2007, pp. 721-29. doi : 10.1016 / j.molcel.2007.11.018 . PMID 18082597 .
  10. ↑ MU Muckenthaler, S Rivella, MW Hentze, B Galy: A Red Carpet for Iron Metabolism . In: Cell . 168, No. 3, January 2017, pp. 344-61. doi : 10.1016 / j.cell.2016.12.034 . PMID 28129536 .
  11. ↑ MW Hentze, T Price: The REM phase of gene regulation . In: Trends Biochem Sci . 35, No. 8, 2010, pp. 423-26. doi : 10.1016 / j.tibs.2010.05.009 . PMID 20554447 .
  12. ^ "REM Networks" . European Research Council website. Retrieved June 2, 2015
  13. ↑ A Castello, B Fischer, K Schuschke, R Horos, BM Beckmann, C Strein, NE Davey, DT Humphreys, T Preiss, LM Steinmetz, J Krijgsveld, MW Hentze: Insights into RNA biology from an atlas of mammalian mRNA-binding proteins . In: Cell . 149, No. 6, June 8, 2016, pp. 1393–1406. doi : 10.1016 / j.cell.2012.04.031 . PMID 22658674 .
  14. ↑ BM Beckmann, R Horos, B Fischer, A Castello, K Eichelbaum, AM Alleaume, T Schwarzl, T Curk, S Foehr, W Huber, J Krijgsveld, MW Hentze: The RNA-binding proteomes from yeast to man harbor conserved enigmRBPs . In: Nature Commun . 6, No. 1012, 2015. doi : 10.1038 / ncomms10127 . PMID 26632259 .
  15. ↑ MW Hentze, A Castello, T Schwarzl, T Price: A brave new world of RNA-binding proteins . In: Nat Rev Mol Cell Biol . 19, No. 5, 2018, pp. 327-41. doi : 10.1038 / nrm.2017.130 . PMID 29339797 .
  16. ↑ A Castello, B Fischer, CK Frese, R Horos, AM Alleaume, S Foehr, T Curk, J Krijgsveld, MW Hentze: Comprehensive identification of RNA-binding domains in human cells . In: Mol. Cell . 63, No. 4, August 18, 2016. doi : 10.1016 / j.molcel.2016.06.029 . PMID 27453046 .
  17. ↑ R Horos, M Büscher, R Kleinendorst, AM Alleaume, AK Tarafder, T Schwarzl, D Dziuba, C Tischer, EM Zielonka, A Adak, A Castello, W Huber, C Sachse, MW Hentze: The Small Non-coding Vault RNA1 -1 Acts as a Riboregulator of Autophagy . In: Cell . 176, No. 5, February 2019, pp. 1054-67. doi : 10.1016 / j.cell.2019.01.030 . PMID 30773316 .
  18. ^ RNA Society News & Announcements. 2020 RNA Society Lifetime Achievement Award. Retrieved January 29, 2020
  19. ↑ Ilse & Helmut Wachter Awardee 2018. Accessed March 30, 2020
  20. ^ American Academy of Arts and Sciences. Newly Elected Fellows. Retrieved May 15, 2018
  21. ↑ Honorary Degree citation: Professor Matthias Hentze MD accessed on February 7, 2020
  22. ↑ Matthias Hentze receives the HMLS Investigator Award . University of Heidelberg. Press release No. 181/2016, December 12, 2016. Accessed March 30, 2020
  23. ^ Profile: Hentze Matthias . Academia Europaea. Retrieved March 30, 2020.
  24. ^ Australian Academy of Science / News and events. Retrieved April 5, 2016
  25. ^ RNA Society. Directors. Retrieved April 4, 2016
  26. ↑ 66th Mosbach Colloquium: Metals in Biology - Cellular Functions and Disease - Program. (PDF; 2.3 MB) (No longer available online.) In: gbm-online.de. Society for Biochemistry and Molecular Biology , archived from the original on February 28, 2017 ; accessed on February 28, 2017 .
  27. ^ ERC Investigator Grant 2011. List of Principal Investigators.
  28. ↑ Lautenschläger Research Prize 2007 to Prof. Dr. Matthias Hentze and Prof. Dr. Andreas Kulozik
  29. ↑ Member entry by Prof. Dr. Matthias W. Hentze (with picture and CV) at the German Academy of Sciences Leopoldina , accessed on July 14, 2016.
  30. ↑ Gottfried Wilhelm Leibniz Program 2000
  31. ↑ EMBO website
  32. ^ Cell Editorial Board. Retrieved August 5, 2015
  33. ↑ RNA Editorial Board. Retrieved August 5, 2015
  34. ↑ EMBO Press - Editors & Advisory Editorial Board. Retrieved August 5, 2015
  35. ↑ TiBS Editorial Board. Retrieved August 5, 2015
  36. ^ Journal of Molecular Medicine Editorial Board. Retrieved August 5, 2015
  37. ^ BMC Molecular Biology Editorial Board. Retrieved August 5, 2015
  38. ^ Wiley Online Library. Retrieved August 5, 2015
  39. ↑ BIG / BIH press release of March 12, 2014. Accessed on April 19, 2017
  40. ^ Comitato Tecnico Scientifico. INGM homepage. Retrieved May 11, 2020
  41. ^ Scientific Advisory Board. Centenary homepage. Retrieved April 19, 2017
  42. ↑ CSH Asia Scientific Advisory Board (2013-2015) CSH Asia Homepage. Retrieved April 19, 2017
  43. ↑ Press Release. Anadys Pharmaceuticals Created. Retrieved April 19, 2017
personal data
SURNAME Hentze, Matthias
ALTERNATIVE NAMES Hentze, Matthias Werner (full name)
BRIEF DESCRIPTION German physician and biochemist
DATE OF BIRTH January 25, 1960
PLACE OF BIRTH Rheda-Wiedenbrück , Germany