Mengovirus

Mengovirus

Classification :	Viruses
Area :	Riboviria
Empire :	Orthornavirae
Phylum :	Pisuviricota
Order :	Picornavirales
Family :	Picornaviridae
Genre :	Cardiovirus

Taxonomic characteristics

Baltimore :

Group 4

Scientific name

Cardiovirus A

Short name

EMCV-1

Left

NCBI Taxonomy:	12107
ICTV Taxon History:	19951533

The Mengovirus (also Cardiovirus A or Encephalomyocarditis Virus 1 for short EMCV-1 ) was first isolated from a rhesus monkey in Entebbe in the Mengo district there . This showed paralysis of the lower extremities. In the mouse experiment, the animals died of acute meningoencephalitis . In humans, the infection is rare and the symptoms are much milder.

application

Genetically modified variants without pathogenicity (vMC0) are used as process controls for the detection of hepatitis A and noroviruses in food. Genetically defused variants can also be used as a vaccine against encephalomyocarditis viruses. The mengovirus can also serve as a vector for vaccines based on recombinant protein .

Web links

Commons : Mengo virus - collection of pictures, videos and audio files

Individual evidence

↑ GWA Dick, KC Smithburn, AJ Haddow: Mengo Encephalomyelitis Virus. Isolation and Immunological Properties . In: British Journal of Experimental Pathology . tape 29 , no. 6 , 1948, ISSN 0007-1021 , pp. 547-558 , PMC 2073198 (free full text).
^ W. Zschiesche, Anneliese Veckenstedt: Pathogenicity of Mengo Virus to Mice . In: Pathobiology . tape 41 , no. 2 , 1974, ISSN 1015-2008 , p. 75-82 , doi : 10.1159 / 000162566 ( karger.com ).
↑ GWA Dick, AJ Haddow, AM Best, KC Smithburn: Mengo Encephalomyelitis . In: The Lancet . tape 252 , no. 6521 , 1948, ISSN 0140-6736 , p. 286-289 , doi : 10.1016 / s0140-6736 (48) 90652-7 .
↑ DIN EN ISO 15216-2: 2019-12, Microbiology of the food chain - Horizontal method for the determination of hepatitis A virus and norovirus in food using real-time RT-PCR - Part 2: Detection method . doi : 10.31030 / 3061337 .
↑ M. Isabel Costafreda, Albert Bosch, Rosa M. Pintó: Development, Evaluation, and Standardization of a Real-Time TaqMan Reverse Transcription-PCR Assay for Quantification of Hepatitis A Virus in Clinical and Shellfish Samples . In: Applied and Environmental Microbiology . tape 72 , no. 6 , 2006, ISSN 0099-2240 , p. 3846-3855 , doi : 10.1128 / AEM.02660-05 , PMID 16751488 ( asm.org ).
↑ Jorge E. Osorio, Gene B. Hubbard, Kenneth F. Soike, Marc Girard, Sylvie van der Werf, Jean-Claude Moulin, Ann C. Palmenberg: Protection of non-murine mammals against encephalomyocarditis virus using a genetically engineered Mengo virus . In: Vaccine . tape 14 , no. 2 , 1996, ISSN 0264-410X , p. 155-161 , doi : 10.1016 / 0264-410X (95) 00129-O ( sciencedirect.com ).
^ R Altmeyer, M Girard, S van der Werf, V Mimic, L Seigneur, MF Saron: Attenuated Mengo virus: a new vector for live recombinant vaccines. In: Journal of Virology . tape 69 , no. 5 , 1995, ISSN 0022-538X , pp. 3193-3196 , PMID 7707549 , PMC 189023 (free full text).

[1] GWA Dick, KC Smithburn, AJ Haddow: Mengo Encephalomyelitis Virus. Isolation and Immunological Properties . In: British Journal of Experimental Pathology . tape 29 , no. 6 , 1948, ISSN 0007-1021 , pp. 547-558 , PMC 2073198 (free full text).

[2] W. Zschiesche, Anneliese Veckenstedt: Pathogenicity of Mengo Virus to Mice . In: Pathobiology . tape 41 , no. 2 , 1974, ISSN 1015-2008 , p. 75-82 , doi : 10.1159 / 000162566 ( karger.com ).

[3] GWA Dick, AJ Haddow, AM Best, KC Smithburn: Mengo Encephalomyelitis . In: The Lancet . tape 252 , no. 6521 , 1948, ISSN 0140-6736 , p. 286-289 , doi : 10.1016 / s0140-6736 (48) 90652-7 .

[4] DIN EN ISO 15216-2: 2019-12, Microbiology of the food chain - Horizontal method for the determination of hepatitis A virus and norovirus in food using real-time RT-PCR - Part 2: Detection method . doi : 10.31030 / 3061337 .

[5] M. Isabel Costafreda, Albert Bosch, Rosa M. Pintó: Development, Evaluation, and Standardization of a Real-Time TaqMan Reverse Transcription-PCR Assay for Quantification of Hepatitis A Virus in Clinical and Shellfish Samples . In: Applied and Environmental Microbiology . tape 72 , no. 6 , 2006, ISSN 0099-2240 , p. 3846-3855 , doi : 10.1128 / AEM.02660-05 , PMID 16751488 ( asm.org ).

[6] Jorge E. Osorio, Gene B. Hubbard, Kenneth F. Soike, Marc Girard, Sylvie van der Werf, Jean-Claude Moulin, Ann C. Palmenberg: Protection of non-murine mammals against encephalomyocarditis virus using a genetically engineered Mengo virus . In: Vaccine . tape 14 , no. 2 , 1996, ISSN 0264-410X , p. 155-161 , doi : 10.1016 / 0264-410X (95) 00129-O ( sciencedirect.com ).

[7] R Altmeyer, M Girard, S van der Werf, V Mimic, L Seigneur, MF Saron: Attenuated Mengo virus: a new vector for live recombinant vaccines. In: Journal of Virology . tape 69 , no. 5 , 1995, ISSN 0022-538X , pp. 3193-3196 , PMID 7707549 , PMC 189023 (free full text).