Methyprylon

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Structural formula
Structural formula of methylprylon
1: 1 mixture of ( R ) -methyprylon (left) and ( S ) -methyprylon (right)
General
Non-proprietary name Methyprylon
other names
  • ( RS ) -3,3-Diethyl-5-methyl-2,4-piperidinedione
  • (±) -3,3-Diethyl-5-methylpiperidine-2,4-dione ( IUPAC )
Molecular formula C 10 H 17 NO 2
External identifiers / databases
CAS number 125-64-4
EC number 204-745-4
ECHA InfoCard 100.004.315
PubChem 4162
DrugBank DB01107
Wikidata Q409558
Drug information
ATC code

N05 CE02

Drug class

Sedative, hypnotic

properties
Molar mass 183.26 g mol −1
Physical state

firmly

Melting point

84.5 ° C ( polymorphic )

solubility

soluble in water, ethanol , diethyl ether and chloroform

safety instructions
Please note the exemption from the labeling requirement for drugs, medical devices, cosmetics, food and animal feed
GHS hazard labeling
no classification available
As far as possible and customary, SI units are used. Unless otherwise noted, the data given apply to standard conditions .

Methyprylon is a drug that has been used as a sedative and hypnotic . It was patented by Hoffmann-La Roche in 1954 and had been on the market in Germany under the trade name Noludar ® since 1955.

From a chemical point of view, it belongs to the group of piperidinediones , just like glutethimide , pyrithyldione and thalidomide . These, in turn, are structural modifications of the barbiturates .

Mechanism of action

The duration of action of Methyprylon corresponds to that of medium-effective barbiturates. It has no advantages over these.

unwanted effects

Long-term use can lead to dependence .

Legal status

Methyprylon is listed in Appendix II of the German Narcotics Act and is therefore one of the marketable but not prescription narcotics.

literature

  • Entry to Methyprylon. In: Römpp Online . Georg Thieme Verlag, accessed on January 2, 2015.
  • HJ Roth, H. Fenner: Medicines . Thieme, Stuttgart a. New York, 1988. pp. 270-271.

Individual evidence

  1. a b H. PT Ammon (Hrsg.): Hunnius Pharmaceutical Dictionary . 9th edition, Walter de Gruyter, Berlin a. New York, 2004. pp. 987. ISBN 978-3-11-017475-5 .
  2. This substance has either not yet been classified with regard to its hazardousness or a reliable and citable source has not yet been found.
  3. Psychiatric Drugs Timeline