Michael Kellner (medic)

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Michael Kellner (born March 20, 1962 in Ulm ) is a German doctor , psychiatrist and psychotherapist , scientist and professor at the University of Hamburg .

Life

Kellner studied medicine and anthropology at the University of Ulm from 1982 to 1988, and in 1989 he was awarded a Dr. med. PhD . Until 1996 he worked as a doctor at the Max Planck Institute for Psychiatry in Munich-Schwabing, where he set up the first German anxiety clinic and became a specialist in psychiatry and psychotherapy. As a scholarship holder of the German Research Foundation , he spent 1996 and 1997 at Mount Sinai Hospital in New York City for a research stay with a focus on post-traumatic stress disorders . He then moved to the University Medical Center Hamburg-Eppendorf as a senior physician , took over the management of the behavioral and neurobiological work area of ​​anxiety spectrum disorders, completed his habilitation in 2001 on "Pharmacological symptom provocations in panic and post-traumatic stress disorder - psychopathological and hormonal reaction patterns" and was appointed professor at the University of Hamburg in 2006 awarded. Since 2014 he has been the chief physician and medical director of a psychosomatic specialist clinic at Chiemsee and has particular clinical psychotherapeutic and psychopharmacological expertise in the treatment of patients with complex stress-related diseases. Since 2018 he has been chief physician at the Clinic for Psychiatry, Psychotherapy and Psychosomatics at the Herford Clinic .

research

To date, Kellner has published well over a hundred, primarily human-experimental, original papers with a focus on psychoneuroendocrinology and experimental psychopathology on patients with anxiety disorders , trauma- related disorders , depression and obsessive-compulsive disorder . He was able to prove for the first time in humans that atrial natriuretic peptide (ANP) shows an inhibitory effect on the stress hormone secretion of the hypothalamus-pituitary-adrenal cortex axis (with the end product cortisol ) that in experimental panic attacks that are accompanied by no increase in cortisol, ANP is released and the panic threshold is increased by prior ANP administration. This offers a starting point for the development of new types of anti-panic drugs that are more effective than previously.

With his research group, he showed that the mineralocorticoid receptor (MR) in the brain has an inhibitory effect on stress hormone secretion in humans too. However, his studies on patients with post-traumatic stress disorder, who often have low cortisol, showed no change in MR function. On the basis of preclinical data, Kellner hypothesized that a pharmacological modulation of the MR could be helpful, especially in depressive disorders. For the first time, he and his group were able to demonstrate in patients with clinical depression that additional administration of the MR agonist fludrocortisone resulted in a faster onset of antidepressant activity.

With various panic-inducing substances, such as B. Lactate or cholecystokinin tetrapeptide, Kellner carried out numerous studies on healthy volunteers and patients for two decades. He summarized the potential of this research approach for the development of new anti-panic agents and for the characterization of the pathophysiology of panic attacks in an important critical review article on the model validity of this strategy. His current further research focuses are the search for biomarkers of anxiety disorders as well as increasing the effectiveness of psychotherapeutic anxiety disorder treatments (in particular exposure therapies) through various substances that promote extinction learning.

Individual evidence

  1. ↑ M. Kellner, K. Wiedemann, F. Holsboer: Atrial natriuretic factor inhibits the CRH-stimulated secretion of ACTH and cortisol in man. In: Life Sci. Volume 50, 1992, pp. 1835-1842.
  2. ↑ M. Kellner, L. Herzog, A. Yassouridis, F. Holsboer, K. Wiedemann: Possible role of atrial natriuretic peptide in pituitary-adrenocortical unresponsiveness in lactate-induced panic. In: Am. J. Psychiatry. Vol. 152, 1995, pp. 1365-1367
  3. ↑ K. Wiedemann, H. Jahn, A. Yassouridis, M. Kellner: Anxiolytic-like effects of atrial natriuretic peptide upon cholecystokinin-tetrapeptide-induced panic attacks. In: Arch. Gen. Psychiatry. Volume 58, 2001, pp. 371-377.
  4. ↑ M. Kellner, H. Jahn, K. Wiedemann: Natriuretic peptides and panic disorder: therapeutic prospects. In: Expert Rev. Neurotherapeutics. Volume 3, 2003, pp. 89-94
  5. ↑ C. Otte, H. Jahn, A. Yassouridis, J. Arlt, N. Stober, P. Maass, K. Wiedemann, M. Kellner: The mineralocorticoid receptor agonist, fludrocortisone, inhibits pituitary-adrenal activity in humans after pre- treatment with metyrapone. In: Life Sci. Volume 73, 2003, pp. 1835-1845
  6. ^ M Kellner, DG Baker, A. Yassouridis, S. Bettinger, D. Naber, K. Wiedemann: Mineralocorticoid receptor function in patients with posttraumatic stress disorder. In: Am. J. Psychiatry. Volume 159, 2002, pp. 1938-1940
  7. ↑ C. Otte, C. Muhtz, S. Daneshkhah, A. Yassouridis, F. Kiefer, K. Wiedemann, M. Kellner: Mineralocorticoid receptor function in PTSD after pre-treatment with metyrapone. In: Biol. Psychiatry. Volume 60, 2006, pp. 784-787
  8. ↑ M. Kellner, K. Wiedemann: Mineralocorticoid receptors in brain, in health and disease: Possibilities for new pharmacotherapy. In: Eur. J. Pharmacol. Volume 583, 2008, pp. 372-378
  9. ↑ C. Otte, K. Hinkelmann, S. Moritz, A. Yassouridis, H. Jahn, K. Wiedemann, M. Kellner: Modulation of the mineralocorticoid receptor as add-on treatment in depression: a randomized, double-blind, placebo -controlled proof-of-concept study. In: J. Psychiatr. Res. Volume 44, 2010, pp. 339-346
  10. ↑ M. Kellner: Experimental panic provocation in healthy man - a translational role in anti-panic drug development? In: Dialogues Clin. Neurosci. Volume 13, 2011, pp. 485-493
personal data
SURNAME Waiter, Michael
BRIEF DESCRIPTION German doctor, psychiatrist and psychotherapist
DATE OF BIRTH March 20, 1962
PLACE OF BIRTH Ulm