N -methylformamide

Structural formula
General
Surname	N -methylformamide
other names	Monomethylformamide; NMF; Methylimido formic acid;
Molecular formula	C 2 H 5 NO
Brief description	colorless liquid with a faint odor
External identifiers / databases
EC number	204-624-6
ECHA InfoCard	100.004.205
PubChem	31254
Wikidata	Q138742
properties
Molar mass	59.07 g mol −1
Physical state	liquid
density	1.00 g ml −1 (20 ° C)
Melting point	−3.2 ° C
boiling point	199-201 ° C
Vapor pressure	0.2 h Pa (20 ° C)
solubility	miscible with water
Refractive index	1.4319 (20 ° C)
safety instructions
H and P phrases	H: 312-319-360D
	P: 280-302 + 352-305 + 351 + 338-308 + 313
	As far as possible and customary, SI units are used. Unless otherwise noted, the data given apply to standard conditions . Refractive index: Na-D line , 20 ° C

N -Methylformamide is a chemical compound from the group of carboxamides .

properties

N -methylformamide is a colorless, toxic liquid. It is an amide of formic acid and has similar properties to formamide , both substances are teratogenic .

use

N -methylformamide is used as a polar solvent (e.g. also in the Karl Fischer method for determining water). It is also used as an intermediate in the manufacture of insecticides. N -methylformamide shows certain anti-tumor effects and is therefore the subject of current medical research.

Individual evidence

↑ ^a ^b ^c ^d ^e ^f ^g ^h ⁱ Entry on N-methylformamide in the GESTIS substance database of the IFA , accessed on January 9, 2019(JavaScript required) .
↑ David R. Lide (Ed.): CRC Handbook of Chemistry and Physics . 90th edition. (Internet version: 2010), CRC Press / Taylor and Francis, Boca Raton, FL, Physical Constants of Organic Compounds, pp. 3-350.
↑ Entry on N-methylformamide in the Classification and Labeling Inventory of the European Chemicals Agency (ECHA), accessed on February 1, 2016. Manufacturers or distributors can expand the harmonized classification and labeling .
↑ US Patent 5466606: Use of N-methylformamide as solvent for the Karl Fischer titration
↑ E. Pagnotta et al .: N-methylformamide and 9-hydroxystearic acid: two anti-proliferative and differentiating agents with different modes of action in colon cancer cells. In: Anticancer Drugs . 2006, 17, 5, pp. 521-6. PMID 16702808

[GESTIS-1] ↑ ^a ^b ^c ^d ^e ^f ^g ^h ⁱ Entry on N-methylformamide in the GESTIS substance database of the IFA , accessed on January 9, 2019(JavaScript required) .

[CRC90_3_350-2] David R. Lide (Ed.): CRC Handbook of Chemistry and Physics . 90th edition. (Internet version: 2010), CRC Press / Taylor and Francis, Boca Raton, FL, Physical Constants of Organic Compounds, pp. 3-350.

[CLP_100.004.205-3] Entry on N-methylformamide in the Classification and Labeling Inventory of the European Chemicals Agency (ECHA), accessed on February 1, 2016. Manufacturers or distributors can expand the harmonized classification and labeling .

[4] US Patent 5466606: Use of N-methylformamide as solvent for the Karl Fischer titration

[5] E. Pagnotta et al .: N-methylformamide and 9-hydroxystearic acid: two anti-proliferative and differentiating agents with different modes of action in colon cancer cells. In: Anticancer Drugs . 2006, 17, 5, pp. 521-6. PMID 16702808