NPC1L1
| NPC1L1 | ||
|---|---|---|
| Properties of human protein | ||
| Mass / length primary structure | 1338 amino acids | |
| Secondary to quaternary structure | Multipass membrane protein (13 TMS) | |
| Isoforms | 3 | |
| Identifier | ||
| Gene name | NPC1L1 | |
| External IDs | ||
| Transporter classification | ||
| TCDB | 2.A.6.6.6 | |
| designation | RND super family | |
| Occurrence | ||
| Homology family | Niemann-Pick C-Type | |
| Parent taxon | Euteleostomi | |
NPC1L1 (from: Niemann-Pick C1-like protein 1 ) is the protein in the cell membrane that facilitates the transport of cholesterol , phytosterols and other lipids into the cell. It is a transporter , although the way of importing it has not yet been fully clarified. NPC1L1 is formed in mammals in many tissue types, in humans mainly in the liver and in the small intestine - enterocytes (where it is mainly responsible for cholesterol absorption from food), but also in the pancreas , kidneys , lungs , spleen , heart , gall bladder , and brain , Testicles , stomach and muscles .
NPC1L1 is the target of the drug ezetimibe and is completely inactivated by it. Mutations in NPC1L1 - gene are thought to be responsible for resistance to ezetimibe.
Individual evidence
- ↑ a b UniProt Q9UHC9
- ↑ D'Eustachio / Jassal / reactome.org: NPC1L1-mediated cholesterol uptake ( page no longer available , search in web archives ) Info: The link was automatically marked as defective. Please check the link according to the instructions and then remove this notice.
- ↑ D'Eustachio / Jassal / reactome.org: NPC1L1-mediated phytosterol uptake ( page no longer available , search in web archives ) Info: The link was automatically marked as defective. Please check the link according to the instructions and then remove this notice.
- ↑ D'Eustachio / Jassal / reactome.org: NPC1L1 inactivation by ezetimibe ( page no longer available , search in web archives ) Info: The link was automatically marked as defective. Please check the link according to the instructions and then remove this notice.
