Sodium butyrate

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Structural formula
Sodium butyrate
General
Surname Sodium butyrate
other names
  • Sodium butanoate
  • Sodium butyricum
  • Butyric acid sodium salt
  • Butanoic acid sodium salt
Molecular formula C 4 H 7 NaO 2
Brief description

hygroscopic white powder with an unpleasant odor

External identifiers / databases
CAS number 156-54-7
EC number 205-857-6
ECHA InfoCard 100.005.326
PubChem 5222465
Wikidata Q305004
properties
Molar mass 110.09 g mol −1
Physical state

firmly

density

0.96 g cm −3

Melting point
  • 244 ° C
  • 250-253 ° C
solubility
safety instructions
GHS labeling of hazardous substances
07 - Warning 08 - Dangerous to health

Caution

H and P phrases H: 315-319-335-341
P: 201-280-305 + 351 + 338-308 + 313-337 + 313
Toxicological data

2940 mg kg −1 ( LD 50 ,  rat ,  oral )

As far as possible and customary, SI units are used. Unless otherwise noted, the data given apply to standard conditions .

Sodium butyrate is a white, hygroscopic sodium salt of butyric acid . It has an unpleasant odor and is stable to light and heat.

synthesis

Sodium butyrate can be produced from sodium hydroxide and butyric acid by the salt formation reaction .

Production of sodium butyrate from caustic soda and butyric acid

use

Sodium butyrate is used as an additive in animal feed. It is used in medicine as a nutrient for intestinal cells and it accelerates the regeneration of the intestinal lining . It also influences the growth of colon cancer cells and is marketed under the name Sobutir ® . Research has shown that sodium butyrate may be useful in the treatment of spinal muscular atrophy . For the prophylaxis of radiogenic proctitis it was registered by the European Commission under the number EU / 3/05/284 in the Community Register for Orphan Medicinal Products.

Individual evidence

  1. ↑ a b c d e f Data sheet sodium butyrate (PDF) from Merck , accessed on May 19, 2010.
  2. ↑ a b Entry at www.chemischemlexikon.de , accessed on May 19, 2010.
  3. ↑ Sodium butyrate data sheet from AlfaAesar, accessed on May 19, 2010 ( PDF )(JavaScript required) .
  4. ↑ Sodium butyrate data sheet from Sigma-Aldrich , accessed on June 13, 2011 ( PDF ).Template: Sigma-Aldrich / name not given
  5. ↑ a b Entry for CAS no. 156-54-7 in the GESTIS substance database of the IFA , accessed on February 1, 2016(JavaScript required) .
  6. ↑ Olof Dietz, Bernhard Huskamp (ed.): Handbuch Pferdepraxis . Georg Thieme Verlag, 2006, ISBN 3-8304-1028-X , p. 443 ( limited preview in Google Book search).
  7. ↑ Aldo Roda, Patrizia Simoni, Maria Magliulo, Paolo Nanni, Mario Baraldini, Giulia Roda, Enrico Roda: A new oral formulation for the release of sodium butyrate in the ileo-cecal region and colon . In: World Journal of Gastroenterology . tape 13 , no. 7 , February 21, 2007, p. 1079-1084 , doi : 10.3748 / wjg.v13.i7.1079 , PMC 4146871 (free full text).
  8. ↑ Instructions for use Sobutir. (PDF; 210 kB) (No longer available online.) In: juvalis.de. Archived from the original on April 12, 2016 ; Retrieved April 12, 2016 . Info: The archive link was inserted automatically and has not yet been checked. Please check the original and archive link according to the instructions and then remove this notice. @1@ 2Template: Webachiv / IABot / www.juvalis.de
  9. ↑ JG Chang, HM Hsieh-Li, YJ Jong, NM Wang, CH Tsai, H. Li: Treatment of spinal muscular atrophy by sodium butyrate. In: Proc Natl Acad Sci USA. 98 (17), Aug 14, 2001, pp. 9808-9813. PMID 11504946 PMC 55534 (free full text).
  10. ↑ EMA: PUBLIC SUMMARY OF POSITIVE OPINION FOR ORPHAN DESIGNATION OF sodium butyrate (rectal use) for the prevention of radiation proctitis (PDF; 53 kB), June 29, 2005.