Oliver Ullrich

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Space medicine specialist and gravitational biologist Oliver Ullrich from the UZH Space Hub, photographed by Regina Sablotny, Berlin

Oliver Ullrich (born July 9, 1970 in Berlin ) is a German space medicine specialist and gravitational biologist.

Life

He studied medicine and biochemistry at the Free University of Berlin from 1989 to 1996 and obtained his doctorate in 1998. med at the Humboldt University in Berlin . To the Dr. rer. nat. he did his doctorate at the Free University. In 2002 he qualified as a professor at the Charité for Anatomy and Cell Biology . In December 2003 he took up a professorship for molecular immunology and later for space biotechnology at the Magdeburg University Hospital . In cooperation with the Faculty of Mechanical Engineering at Otto von Guericke University Magdeburg , he founded space biology research that received international attention. In addition, he worked on the networking of neurosciences and immunology, participated in a state research association and founded a DFG graduate school.

Since September 2007 he has been a full professor of anatomy at the Anatomical Institute of the University of Zurich in Switzerland. He is also an adjunct professor at the Beijing Institute of Technology (BIT) in China .

Ullrich led international space medicine and gravitational biology research projects. Among others CELLBOX-PRIME, TRIPLE LUX A, FLUMIAS-DEA and Gene Control Prime. He deals with gravitational biology and is particularly concerned with the molecular adaptation of human cells to different gravity conditions. He wants to find out how body cells perceive gravity and how they react to its change. He is particularly interested in immune cells and cells of the musculoskeletal system. He investigates their gravitational behavior on different platforms: parabolic flights, suborbital rockets and on the international international space station ISS . He also carried out an orbital experiment in the German-Chinese space project SIMBOX on Shenzhou-8 . In applied research he works on the possibility of producing tissues and organs in weightlessness. A research result that he published together with Cora Thiel after experiments on the ISS in 2017 received worldwide attention: According to this, immune cells of mammals adapt completely to weightlessness in less than a minute. He and his team also found rapid adaptation processes in other cell types. He is currently researching how this adaptation comes about. His research results contribute to the risk assessment of manned space missions.

In 2012, Oliver Ullrich was elected a lifetime academician of the International Academy of Astronautics . He is President of the Swiss SkyLab Foundation and Director of Swiss Parabolic Flights . 2015 he founded the Magdeburg Association for Research under space and microgravity conditions (MARS) at the Otto-von-Guericke-University of Magdeburg in 2016 he was appointed to the board of the German Society of Aerospace Medicine selected (DGLRM) and 2019. He to the Vice President is a member of the program committee of the German Aerospace Center (DLR). In addition, he is a member of various other international bodies in the space sector. Ullrich is also director of the UZH Space Hub - an innovation platform at the University of Zurich .

Ullrich is co-editor of various scientific journals, u. a. for Scientific Reports (Nature Publishing Group) and Acta Astronautica (Elservier), the official scientific journal of the International Academy of Astronautics.

Awards

Between 2000 and 2003, Oliver Ullrich won the Karl Asmund Rudolphi Prize three times for the best teaching at the Charité Berlin. In 2002 he was awarded the Wolfgang Bargmann Prize of the Anatomical Society, in 2004 the State Research Prize Saxony-Anhalt and in 2006 the Otto von Guericke Prize . He has been awarded the parabolic flight medal in bronze and silver. In 2009 he was allowed to enter himself in the Golden Book of the city of Magdeburg . In 2017 he was elected professor of the year at the Medical Faculty of the University of Zurich. In 2018 the German Academy for Aviation and Travel Medicine (DAF) awarded Ullrich, together with Cora Thiel, the Albrecht Ludwig Berblinger Science Prize for their research work "Rapid adaptation of microgravity in mammalian macrophage cells".

additional

Together with the air force officer and physician Marc Studer, he initiated and led the development of a weightlessness research platform on a fighter aircraft of the Swiss Air Force. With Natalie Dove he set up the Swiss Parabolic Flight program, which, by combining teams of scientists with industry and private individuals, enables research flights with the A310 ZERO-G from Dübendorf airfield without the use of taxpayers' money. In 2011, together with Cora Thiel, Ullrich succeeded in proving experimentally that the genetic material DNA can survive the space environment and the entry into the earth's atmosphere and is still functional afterwards. The publication of this study in 2014 received worldwide attention. Oliver Ullrich is considered the first West student in the GDR after the fall of the Berlin Wall.

Works

  • Rapid coupling between gravitational forces and the transcriptome in human myelomonocytic U937 cells, 2017
  • Stability of gene expression in human T cells in different gravity environments is clustered in chromosomal region 11p15.4, 2017
  • Rapid adaptation to microgravity in mammalian macrophage cells, 2017
  • Functional Activity of Plasmid DNA after Entry into the Atmosphere of Earth Investigated by a New Biomarker Stability Assay for Ballistic Spaceflight Experiments , 2014
  • Metabolic effect of the lipid peroxidation product 4-hydroxynonenal on poly-ADP-ribosylation in primary synovial fibroblasts , 1998
  • Function and regulation of the nuclear 20S proteasome in the breakdown of oxidatively damaged histones in human K562 cells , 1998
  • Mechanisms of protective and destructive functions of poly (ADP-ribose) -polymerase-1 (PARP-1) in cell and tissue damage 2002

Web links

Individual evidence

  1. ↑ Experiment details. Retrieved April 22, 2020 .
  2. ↑ Experiment details. Retrieved April 22, 2020 .
  3. ↑ Experiment details. Retrieved April 22, 2020 .
  4. ↑ Experiment details. Retrieved April 22, 2020 .
  5. ↑ PROF. DR. MED. DR.RER.NAT. OLIVER ULLRICH on www.dglrm.de
  6. ↑ Oliver Ullrich. Retrieved April 22, 2020 (English).
  7. ↑ DLR - Space Administration - SIMBOX - A German-Chinese space cooperation. Retrieved April 22, 2020 .
  8. ↑ Experiment details. Retrieved April 22, 2020 .
  9. ^ Cora S. Thiel, Diane de Zélicourt, Svantje Tauber, Astrid Adrian, Markus Franz: Rapid adaptation to microgravity in mammalian macrophage cells . In: Scientific Reports . tape 7 , no. 1 , February 27, 2017, ISSN  2045-2322 , p. 1–13 , doi : 10.1038 / s41598-017-00119-6 ( nature.com [accessed April 22, 2020]).
  10. ↑ 42 is the answer. Retrieved April 22, 2020 (English).
  11. ↑ Mammalian cells adjust to weightlessness amazingly quickly - derStandard.at. Retrieved April 22, 2020 (Austrian German).
  12. ↑ Oliver Ullrich, Cora S. Thiel: Fast cellular reaction and adaptation to weightlessness . In: Aviation Medicine · Tropical Medicine · Travel Medicine - FTR . tape 26 , no. October 05 , 2019, ISSN  1864-4538 , p. 202–205 , doi : 10.1055 / a-0990-3284 ( thieme-connect.de [accessed April 22, 2020]).
  13. ^ Cora S. Thiel, Svantje Tauber, Swantje Christoffel, Andreas Huge, Beatrice A. Lauber: Rapid coupling between gravitational forces and the transcriptome in human myelomonocytic U937 cells . In: Scientific Reports . tape 8 , no. 1 , September 5, 2018, ISSN  2045-2322 , p. 1-24 , doi : 10.1038 / s41598-018-31596-y ( nature.com [accessed April 22, 2020]).
  14. ^ Cora Sandra Thiel, Swantje Christoffel, Svantje Tauber, Christian Vahlensieck, Diane de Zélicourt: Rapid Cellular Perception of Gravitational Forces in Human Jurkat T Cells and Transduction into Gene Expression Regulation . In: International Journal of Molecular Sciences . tape 21 , no. 2 , January 14, 2020, p. 514 , doi : 10.3390 / ijms21020514 ( mdpi.com [accessed April 22, 2020]).
  15. ↑ Stephan Jaensch, Jan Vesper, Marian Gaebler, Kristopher Jelinek, Philip Richter (layout, HTML, CSS) -intosite GmbH: Otto-von-Guericke-University becomes a location for space research. Retrieved April 22, 2020 .
  16. ↑ 2020-2022. Accessed April 16, 2020 (German).
  17. ↑ Start of the festival year "20 Years OVGU" on www.ovgu.de
  18. ↑ Editors | Scientific Reports. Retrieved April 22, 2020 (English).
  19. ^ Acta Astronautica . ( elsevier.com [accessed April 22, 2020]).
  20. ↑ Oliver Ullrich. Retrieved April 16, 2020 .
  21. ↑ Awarded the Albrecht Ludwig Berblinger Prize 2018. Accessed on April 16, 2020 .
  22. ↑ Marc Studer, Gesine Bradacs, Andre Hilliger, Eva Hürlimann, Stephanie Engeli: Parabolic maneuvers of the Swiss Air Force fighter jet F-5E as a research platform for cell culture experiments in microgravity . In: Acta Astronautica . tape 68 , no. 11 , June 1, 2011, ISSN  0094-5765 , p. 1729–1741 , doi : 10.1016 / j.actaastro.2010.11.005 ( sciencedirect.com [accessed April 20, 2020]).
  23. ↑ Alois Feusi: With the fighter jet to the dissertation. NZZ, January 22, 2010, accessed on April 20, 2020 .
  24. ↑ www 20minuten ch, 20 minutes, 20 min. Www.20min.ch: Nose ahead in space research. Retrieved April 20, 2020 .
  25. ↑ Switzerland in space - TV. Retrieved April 20, 2020 .
  26. ^ Cora S. Thiel, Svantje Tauber, Andreas Schütte, Burkhard Schmitz, Harald Nuesse: Functional Activity of Plasmid DNA after Entry into the Atmosphere of Earth Investigated by a New Biomarker Stability Assay for Ballistic Spaceflight Experiments . In: PLoS ONE . tape 9 , no. 11 , November 26, 2014, ISSN  1932-6203 , p. e112979 , doi : 10.1371 / journal.pone.0112979 , PMID 25426925 , PMC 4245111 (free full text) - ( plos.org [accessed April 20, 2020]).
  27. ↑ Manfred Lindinger: Robust genetic material: Once space and back . In: FAZ.NET . ISSN  0174-4909 ( faz.net [accessed April 20, 2020]).
  28. ↑ Did our DNA arrive from space? Retrieved April 20, 2020 (English).
  29. ↑ "Hello. I come from the west". November 6, 2009, accessed April 20, 2020 .
  30. ^ Cora S. Thiel, Svantje Tauber, Swantje Christoffel, Andreas Huge, Beatrice A. Lauber: Rapid coupling between gravitational forces and the transcriptome in human myelomonocytic U937 cells . In: Scientific Reports . tape 8 , no. 1 , September 5, 2018, ISSN  2045-2322 , p. 1–24 , doi : 10.1038 / s41598-018-31596-y ( nature.com [accessed April 16, 2020]).
  31. ^ Cora S. Thiel, Andreas Huge, Swantje Hauschild, Svantje Tauber, Beatrice A. Lauber: Stability of gene expression in human T cells in different gravity environments is clustered in chromosomal region 11p15.4 . In: npj Microgravity . tape 3 , no. 1 , August 31, 2017, ISSN  2373-8065 , p. 1–20 , doi : 10.1038 / s41526-017-0028-6 ( nature.com [accessed April 16, 2020]).
  32. ↑ Thiel, Cora S de Zélicourt, Diane Tauber, Svantje Adrian, Astrid Franz, Markus Simmet, Dana M Schoppmann, Kathrin Hauschild, Swantje Krammer, Sonja Christen, Miriam Bradacs, Gesine Paulsen, Katrin Wolf, Susanne A Braun, Markus Hatton, Jason Kurtcuoglu, Vartan Franke, Stefanie Tanner, Samuel Cristoforetti, Samantha Sick, Beate Hock, Bertold Ullrich, Oliver: Rapid adaptation to microgravity in mammalian macrophage cells . Nature Publishing Group, February 27, 2017 ( worldcat.org [accessed April 16, 2020]).
  33. ^ Cora S. Thiel, Svantje Tauber, Andreas Schütte, Burkhard Schmitz, Harald Nuesse: Functional Activity of Plasmid DNA after Entry into the Atmosphere of Earth Investigated by a New Biomarker Stability Assay for Ballistic Spaceflight Experiments . In: PLOS ONE . tape 9 , no. 11 , November 26, 2014, ISSN  1932-6203 , p. e112979 , doi : 10.1371 / journal.pone.0112979 , PMID 25426925 , PMC 4245111 (free full text) - ( plos.org [accessed April 16, 2020]).
personal data
SURNAME Ullrich, Oliver
BRIEF DESCRIPTION German space doctor
DATE OF BIRTH July 9, 1970
PLACE OF BIRTH Berlin