Trimethyl orthoacetate
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| General | |||||||||||||||||||
| Surname | Trimethyl orthoacetate | ||||||||||||||||||
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| Molecular formula | C 5 H 12 O 3 | ||||||||||||||||||
| Brief description |
colorless liquid |
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| properties | |||||||||||||||||||
| Molar mass | 120.15 g mol −1 | ||||||||||||||||||
| Physical state |
liquid |
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| density |
0.956 g cm −3 |
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| boiling point |
107-109 ° C |
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| Vapor pressure |
20 hPa (20 ° C) |
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| solubility |
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| Refractive index |
1.3890 (20 ° C) |
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| As far as possible and customary, SI units are used. Unless otherwise noted, the data given apply to standard conditions . Refractive index: Na-D line , 20 ° C | |||||||||||||||||||
Trimethyl orthoacetate is a chemical compound from the group of orthoesters .
Extraction and presentation
The compound can be obtained by a two-step reaction of acetonitrile with methanol and hydrogen chloride .
properties
Trimethyl orthoacetate is a colorless liquid that hydrolyzes in water.
use
Trimethyl orthoacetate is mainly used as an intermediate in the manufacture of pharmaceuticals, agrochemicals and in the dye and spice industries, such as the manufacture of vitamin B1 , brinzolamide and sulfanilamide .
Individual evidence
- ↑ a b c d e f g h i j data sheet Trimethyl orthoacetate, 98% from AlfaAesar, accessed on January 26, 2019 ( PDF )(JavaScript required) .
- ↑ a b Data sheet trimethyl orthoacetate (PDF) from Merck , accessed on January 26, 2019.
- ↑ David R. Lide: CRC Handbook of Chemistry and Physics A Ready-reference Book of Chemical and Physical Data . CRC Press, 1995, ISBN 978-0-8493-0595-5 , pp. 552 ( limited preview in Google Book search).
- ↑ Google Patents: CN105384614A - Trimethyl orthoacetate synthesis method , accessed January 26, 2019
- ↑ Justia Patents Search: US Patent for Process for the preparation of brinzolamide Patent (Patent # 8,344,136 issued January 1, 2013) , accessed January 26, 2019