Oxipurinol

Structural formula
General
Non-proprietary name	Oxipurinol
other names	1,2-dihydropyrazolo [4,3- e ] pyrimidine-4,6-dione ( IUPAC ); Alloxanthin;
Molecular formula	C 5 H 4 N 4 O 2
Brief description	colorless, needle-shaped crystals
External identifiers / databases
EC number	219-570-9
ECHA InfoCard	100.017.792
PubChem	4644
ChemSpider	4483
DrugBank	DB05262
Wikidata	Q410588
properties
Molar mass	152.11 g mol −1
Physical state	firmly
Melting point	> 320 ° C
safety instructions
GHS labeling of hazardous substances danger
H and P phrases	H: 315-319-335
	P: 261-305 + 351 + 338
	As far as possible and customary, SI units are used. Unless otherwise noted, the data given apply to standard conditions .

Oxipurinol is a chemical compound from the group of pyrazoles . The substance acts in the metabolism by inhibiting the formation of uric acid . Excessively high uric acid levels can lead to the development of kidney and urinary stones and gout .

Oxipurinol is the main active metabolite of the drug allopurinol , but is not used as a drug itself.

Mechanism of action

Oxipurinol inhibits the enzyme xanthine oxidase , which oxidizes xanthine , an intermediate product in purine breakdown, to uric acid. As a result, more xanthine and hypoxanthine are excreted in the urine , causing the uric acid level in the blood and urine to drop.

Oxypurinol is excreted renally unchanged .

Individual evidence

^ ^A ^b Elvira A. Falco, George H. Hitchings: Studies on Condensed Pyrimidine Systems. XV. Some pyrazolo [3,4-d] pyrimidines . In: Journal of the American Chemical Society . tape 78 , no. 13 , 1956, pp. 3143–3145 , doi : 10.1021 / ja01594a046 .

↑ ^a ^b Oxipurinol data sheet from Sigma-Aldrich , accessed on June 24, 2011 ( PDF ).

[Falco-1] A ^b Elvira A. Falco, George H. Hitchings: Studies on Condensed Pyrimidine Systems. XV. Some pyrazolo [3,4-d] pyrimidines . In: Journal of the American Chemical Society . tape 78 , no. 13 , 1956, pp. 3143–3145 , doi : 10.1021 / ja01594a046 .