PLCB4
| 1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase-β 4 | ||
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| other names |
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| Properties of human protein | ||
| Mass / length primary structure | 1174 amino acids | |
| Cofactor | Ca 2+ | |
| Isoforms | 4 (+ 4 potential [computer-aided]) | |
| Identifier | ||
| Gene names | PLCB4 ; ARCND2, PI-PLC | |
| External IDs | ||
| Enzyme classification | ||
| EC, category | 3.1.4.11 , hydrolase | |
| Response type | Hydrolysis of orthophosphoric acid ester bonds | |
| Substrate | Phosphatidylinositol 4,5-bisphosphate | |
| Products | Inotisol 1,4,5-trisphosphate + diacylglycerin | |
| Occurrence | ||
| Homology family | CLU_002738_2_1 | |
| Parent taxon | Boreoeutheria | |
| Orthologue | ||
| human | House mouse | |
| Entrez | 5332 | 18798 |
| Ensemble | ENSG00000101333 | ENSMUSG00000039943 |
| UniProt | Q15147 | |
| Refseq (mRNA) | NM_000933 | NM_013829 |
| Refseq (protein) | NP_000924 | |
| Gene locus | Chr 20: 9.07 - 9.48 Mb | Chr 2: 135.66 - 136.01 Mb |
| PubMed search | 5332 |
18798
|
1- phosphatidylinositol -4,5-bisphosphat- phosphodiesterase -β 4 is an enzyme which, when people through the PLCB4 - gene is encoded.
function
The protein encoded by this gene catalyzes the formation of inotisol-1,4,5-trisphosphate and diacylglycerol from phosphatidylinositol-4,5-bisphosphate . This response uses calcium as a cofactor and plays an important role in the intracellular transduction of many extracellular signals in the retina . Two transcript variants that code for different isoforms were found for this gene .
Up-regulation of PLCB4 is associated with an unfavorable prognosis in children with acute myeloid leukemia (AML) and could therefore act as a potential prognostic biomarker and therapeutic target for AML.
Individual evidence
- ↑ RA Alvarez, AJ Ghalayini, P. Xu, A. Hardcastle, S. Bhattacharya, PN Rao, MJ Pettenati, RE Anderson, W. Baehr: cDNA sequence and gene locus of the human retinal phosphoinositide-specific phospholipase C beta 4 ( PLCB4). In: Genomics. Volume 29, Number 1, September 1995, pp. 53-61, doi : 10.1006 / geno.1995.1214 , PMID 8530101 .
- ↑ a b Entrez Gene: PLCB4 phospholipase C, beta 4 .
- ↑ Shiwen Wu, Wei Zhang, Dongqin Shen, Jianle Lu, Li Zhao: PLCB4 upregulation is associated with unfavorable prognosis in pediatric acute myeloid leukemia. In: Oncology Letters. 2019, doi : 10.3892 / ol.2019.10921 .