p -aminohippuric acid
Structural formula | ||||||||||||||||||||||
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General | ||||||||||||||||||||||
Surname | P-aminohippuric acid | |||||||||||||||||||||
other names |
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Molecular formula | C 9 H 10 N 2 O 3 | |||||||||||||||||||||
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properties | ||||||||||||||||||||||
Molar mass | 194.19 g mol −1 | |||||||||||||||||||||
Physical state |
firmly |
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Melting point |
199-200 ° C |
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safety instructions | ||||||||||||||||||||||
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As far as possible and customary, SI units are used. Unless otherwise noted, the data given apply to standard conditions . |
p -Aminohippuric acid , also paraaminohippuric acid or 4-aminohippuric acid , is a chemical compound derived from hippuric acid . It is used in particular as a diagnostic tool for examining kidney function . As a condensation product of p- aminobenzoic acid and the amino acid glycine , it can occur in the human body as a metabolic product .
synthesis
p-Aminohippuric acid can be prepared by condensation of p-aminobenzoic acid with glycine. When using dehydrating agents this happens faster, but less clean. A more elegant method of preparation is the nitration of hippuric acid to p-nitrohippuric acid and subsequent reduction with a selective reducing agent to p-aminohippuric acid.
use
To examine kidney function and calculate renal blood flow , p- aminohippuric acid is administered as an infusion . Since p- aminohippuric acid is almost completely excreted by the kidneys via glomerular filtration (20–30%) and tubular secretion (70%), its clearance , the PAH clearance , corresponds to the renal plasma flow . This is used to calculate the renal blood flow.
Related links
- Sodium p-aminohippurate
Individual evidence
- ↑ a b c Data sheet 4-Aminohippuric acid from Sigma-Aldrich , accessed on May 31, 2018 ( PDF ).
- ↑ External identifiers or database links for sodium p-aminohippurate : CAS number: 94-16-6, EC number: 202-309-8, ECHA InfoCard: 100.002.100 , PubChem : 443971 , ChemSpider : 6910 , DrugBank : DBSALT000352 , Wikidata : Q27114208 .