Peter Dervan
Peter B. Dervan (born June 28, 1945 in Boston ) is an American chemist who deals with bio-organic chemistry.
biography
Dervan studied at Boston College (Bachelor in 1967) and received his PhD in organic physical chemistry from Yale University in 1972 with Jerome A. Berson . As a post-doctoral student, he was a Fellow of the National Institutes of Health (NIH) at Stanford University . He has been Professor at Caltech since 1973 ( Bren Professor of Chemistry ).
Dervan is a member of the National Academy of Sciences and the Institute of Medicine, the American Academy of Arts and Sciences (1988), the American Philosophical Society (2002), an external member of the Académie des sciences and a member of the Leopoldina since 2004 . In 2017 he was elected a Fellow of the American Association for the Advancement of Science .
He is married to chemistry professor Jacqueline K. Barton .
plant
Dervan developed novel synthetic molecules that are comparable in their affinity and specificity to any given DNA sequence in naturally occurring proteins. He opened up a completely new field of bio-organic chemistry. It also enables novel drugs to combat cancer and other diseases caused by abnormal gene expression by synthesizing small molecules that enter the cell and bind to predetermined DNA sites.
Honors
- 1977: Sloan Research Fellow
- 1988: Harrison Howe Award
- 1993: Arthur C. Cope Award
- 1993: Willard Gibbs Medal
- 1994: William H. Nichols Medal
- 1996: Maison de la Chimie Foundation Prize
- 1998: Kirkwood Medal
- 1998: Remsen Award
- 1999: Max Tishler Prize
- 1999: Richard C. Tolman Medal
- 1999: Alfred Bader Award
- 1999: Linus Pauling Award
- 2000: Tetrahedron Prize
- 2002: Harvey Prize
- 2005: Wilbur Cross Medal
- 2005: Ronald Breslow Award
- 2006: National Medal of Science
- 2012: Namesake for the asteroid (4314) Dervan
Fonts (selection)
- with HE Moser Sequence specific cleavage of double helical DNA by triple helix formation , Science, Volume 238, 1987, pp. 645-650
- with S. White, JW Szewczyk, JM Turner, EE Baird Recognition of the four Watson-Crick base pairs in the DNA minor groove by synthetic ligands , Nature, Volume 391, 1998, pp. 468-471
- with CL Kielkopf, S. White, JW Szewczyk, JM Turner, EE Baird, D. Rees A structural basis for recognition of TA and AT base pairs in the minor groove of B-DNA , Science, Volume 282, 1998, p. 111 -115
Web links
Individual evidence
- ^ Biographical data, publications and academic family tree of Peter B. Dervan at academictree.org, accessed on January 29, 2018.
- ↑ Member entry of Peter B. Dervan at the German Academy of Natural Scientists Leopoldina , accessed on December 10, 2012.
- ^ Fellows of the AAAS: PB Dervan. American Association for the Advancement of Science, accessed March 11, 2018 .
- ↑ Laudation for acceptance into the Leopoldina. New members of the Leopoldina 2004, PDF p. 22.
| personal data | |
|---|---|
| SURNAME | Dervan, Peter |
| ALTERNATIVE NAMES | Dervan, Peter B. |
| BRIEF DESCRIPTION | American chemist |
| DATE OF BIRTH | June 28, 1945 |
| PLACE OF BIRTH | Boston |