Pizotifen

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Structural formula
Structural formula of pizotifen
General
Surname Pizotifen
other names
  • Pizotyline ( USAN )
  • 4- (1-Methyl-4-piperidylidine) -9,10-dihydro-4 H -benzo- [4,5] cyclohepta [1,2] -thiophene ( IUPAC )
Molecular formula C 19 H 21 NS
External identifiers / databases
CAS number 15574-96-6
EC number 239-632-9
ECHA InfoCard 100.036.014
PubChem 27400
ChemSpider 25497
DrugBank DB06153
Wikidata Q413784
Drug information
ATC code

N02 CX01

Drug class

Migraine drugs

Mechanism of action

Antagonism at serotonin receptors

properties
Molar mass 295.44 g · mol -1
Melting point

197-198 ° C (dec); 185-186 ° C (malate, decomp.)

pK s value

7.0

safety instructions
Please note the exemption from the labeling requirement for drugs, medical devices, cosmetics, food and animal feed
GHS labeling of hazardous substances
07 - Warning 08 - Dangerous to health

Caution

H and P phrases H: 302-361
P: ?
As far as possible and customary, SI units are used. Unless otherwise noted, the data given apply to standard conditions .

The drug pizotifen was previously used for interval treatment of migraines and for migraine prophylaxis . It was also used against a lack of appetite . The malate is used .

Pizotifen was patented by Sandoz in 1966 and was on the market under the trade names Mosegor ® and Sandomigran ® .

Pharmacological properties

The drug is an antagonist of serotonin receptors and also has an antihistamine effect.

literature

  • Ernst Mutschler: drug effects . 7th edition. Wissenschaftliche Verlagsgesellschaft, Stuttgart 1996, pp. 224–225 u. 393-394, ISBN 3-8047-1377-7 .

Individual evidence

  1. ↑ a b c d e Entry on Pizotifen. In: Römpp Online . Georg Thieme Verlag, accessed on July 24, 2019.
  2. ↑ Template: CL Inventory / not harmonized There is not yet a harmonized classification for this substance . A labeling of pizotifen in the Classification and Labeling Inventory of the European Chemicals Agency (ECHA), which was accessed on July 11, 2020, is reproduced from a self-classification by distributors .