Prifinium bromide
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| Non-proprietary name | Prifinium bromide | ||||||||||||||||||
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3- (Diphenylmethylene) -1,1-diethyl-2-methylpyrrolidinium bromide ( IUPAC ) |
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| Molecular formula | C 22 H 28 BrN | ||||||||||||||||||
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| Molar mass | 386.38 g mol −1 | ||||||||||||||||||
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| As far as possible and customary, SI units are used. Unless otherwise noted, the data given apply to standard conditions . | |||||||||||||||||||
Prifinium bromide is a drug from the group of 3-pyrrolidone derivatives , which belongs to the synthetic parasympatholytics . It is used for spasms of the esophagus , gastrointestinal tract and urinary organs . Currently, only veterinary medicinal products are approved in Germany.
The pharmacological effect corresponds to that of butylscopolamine . It competitively inhibits the action of acetylcholine on the muscarinic receptors , whereby it binds relatively strongly to the receptor subtype M 4 . This leads to an inhibition of the parasympathetic influence on the smooth muscles , the heart muscle , glands and ganglia of the peripheral nervous system . As a quaternary ammonium compound, it only reaches the central nervous system to a very small extent .
Contraindications for use are glaucoma , enlarged prostate , intestinal obstruction , pyloric stenosis and other constrictions in the gastrointestinal tract as well as cardiac arrhythmias with increased heart rate. In the case of liver or kidney diseases, the agent should only be used under strict indications.
A dry oral cavity and dilation of the pupil can occur as side effects .
Trade name
- Veterinary medicine: Prifinial (CH)
Web links
- Entry on Prifinium at Vetpharm, accessed on August 4, 2012.
Individual evidence
- ↑ There is not yet a harmonized classification for this substance . A labeling of Prifinium bromide in the Classification and Labeling Inventory of the European Chemicals Agency (ECHA), which was accessed on March 4, 2020, is reproduced from a self-classification by the distributor .
