Pyrvinium

Structural formula
	Structure of pyrvinium embonate
General
Non-proprietary name	Pyrvinium
other names	{6-Dimethylamino-2- [2- (2,5-dimethyl-1-phenyl-1 H -pyrrol-3-yl) ethenyl] -1-methylquinolin-1-ium} - [4,4'-methylenebis ( 3-hydroxynaphthalene-2-carboxylate)] (2: 1); Bis {6-dimethylamino-2- [2- (2,5-dimethyl-1-phenylpyrrol-3-yl) vinyl] -1-methylquinolinium} - [4,4'-methylenebis (3-hydroxy-2-naphthoate) ] ( IUPAC ) ; Pyrvinium emboat; Viprynium emboat; Pyrvinium hemimbonate;
Molecular formula	C 75 H 70 N 6 O 6
Brief description	light to dark orange solid (pyrvinium embonate)
External identifiers / databases
EC number	222-596-3
ECHA InfoCard	100.020.543
PubChem	54680693
Wikidata	Q27166587
Drug information
ATC code	P02 CX01
Drug class	Anthelmintic
Mechanism of action	Disruption of sugar intake
properties
Molar mass	1151.42 g · mol -1
Melting point	210–215 ° C (Embonat) ; 249-251 ° C (pyrvinium chloride dihydrate, decomp.) ;
solubility	practically insoluble in water and ether, soluble in ethanol , chloroform and methoxyethanol
safety instructions
	Please note the exemption from the labeling requirement for drugs, medical devices, cosmetics, food and animal feed
H and P phrases	H: 302-312-315-319-332-335-351
	P: 261-280-305 + 351 + 338
Toxicological data	200 mg kg −1 ( LD 50 , mouse , sc , pyrvinium emboat)
	As far as possible and customary, SI units are used. Unless otherwise noted, the data given apply to standard conditions .

Pyrvinium is a medicinal substance against worm diseases of the digestive tract in humans. Pyrvinium belongs to the group of quinolinium salts .

Drug

The active ingredient is used as a salt of emboxylic acid (pamoic acid). Pyrvinium embonate or pyrvinium pamoate is a crystalline salt with a bright orange-red color. It does not dissolve in water. Pyrviniumemboat is formulated as a dragee or suspension using suitable auxiliary substances.

application

Pyrvinium is effective against pinworms ( oxyuriasis ). The drug causes the worms to die by disrupting the uptake of sugar, as they can no longer feed themselves adequately. Apparently only a small percentage of pyrvinium is absorbed into the bloodstream.

Trade names

Monopreparations

Molevac (D), Pyrcon (D), Povanyl (F)

Web links

Pyrvinium at Mayoclinic

Individual evidence

↑ ^a ^b entry on pyrvinium chloride. In: Römpp Online . Georg Thieme Verlag, accessed on September 18, 2011.
↑ ^a ^b Merck Index Fourteenth Edition . MERCK & CO. INC., Whitehouse Station, NJ, USA 2006, ISBN 0-911910-00-X (English).
↑ ^a ^b ^c Data sheet Pyrvinium pamoate salt hydrate from Sigma-Aldrich , accessed on April 22, 2011 ( PDF ).
↑ DESAI AS: Single-dose treatment of oxyuriasis with pyrvinium embonate . In: British Medical Journal . Vol. 2, No. 5319 , December 1962, p. 1583–1585 , PMID 14027194 , PMC 1926864 (free full text) - (English).

[roempp-1] try on pyrvinium chloride. In: Römpp Online . Georg Thieme Verlag, accessed on September 18, 2011.

[Merck_Index-2] Merck Index Fourteenth Edition . MERCK & CO. INC., Whitehouse Station, NJ, USA 2006, ISBN 0-911910-00-X (English).

[Sigma-3] Data sheet Pyrvinium pamoate salt hydrate from Sigma-Aldrich , accessed on April 22, 2011 ( PDF ).

[pmid14027194-4] DESAI AS: Single-dose treatment of oxyuriasis with pyrvinium embonate . In: British Medical Journal . Vol. 2, No. 5319 , December 1962, p. 1583–1585 , PMID 14027194 , PMC 1926864 (free full text) - (English).