RDL receptor
| RDL receptor | ||
|---|---|---|
| other names |
GD12940 |
|
| Mass / length primary structure | 29,138 Da , 256 amino acids | |
| Identifier | ||
| External IDs | ||
| Enzyme classification | ||
| EC, category | , GABA receptor | |
| Occurrence | ||
| Parent taxon | Invertebrates | |
The RDL receptor ( resistance to dieldrin , resistance to dieldrin) is a receptor from the group of GABA A receptors . The RDL receptor belongs to the Cys-loop family of GABA receptors. It is a target in insecticide development .
properties
As a GABA receptor, the RDL receptor is a GABA -controlled ion channel for chloride ions in certain nerve cells . The RDL receptor occurs in insects mainly in the mushroom bodies and is involved in olfactory learning processes. An overexpression of RDL receptor results in fruit flies in an inhibition of the original purchase of olfactory associations, while the receipt of the associations remains unchanged. In contrast, a gene knockdown of the RDL receptor leads to improved learning. The RDL receptor is involved in the habituation to male competition in the mating behavior of fruit flies.
Synthetic non-competitive ligands of the RDL receptor are e.g. B. lindane and some cyclodienes such as dieldrin , α-endosulfan and fipronil . Further inhibitors of the RDL receptor are the neonicotinoid imidacloprid and the pyrethroid deltamethrin as well as the meta-diamide broflanilid . Various mutations have been described that confer resistance to inhibitors of the RDL receptor. Meta-Diamides bind to different areas of the RDL receptor compared to cyclodienes.
literature
- I. McGonigle, SC Lummis: RDL receptors. In: Biochemical Society transactions. Volume 37, Pt 6, December 2009, pp. 1404-1406, doi : 10.1042 / BST0371404 , PMID 19909285 .
Individual evidence
- ↑ a b c Resistant to dieldrin. In: sdbonline.org Interactive Fly. Retrieved August 18, 2016 .
- ↑ S. Tachibana, K. Touhara, A. Ejima: Modification of Male Courtship motivation by Olfactory habituation via the GABAA receptor in Drosophila melanogaster. In: PloS one. Volume 10, number 8, 2015, p. E0135186, doi : 10.1371 / journal.pone.0135186 , PMID 26252206 , PMC 4529276 (free full text).
- ↑ T. Nakao: Mechanisms of resistance to insecticides targeting RDL GABA receptors in planthoppers. In: Neurotoxicology. [Electronic publication before printing] March 2016, doi : 10.1016 / j.neuro.2016.03.009 , PMID 27000517 .
- ^ A b J. Taylor-Wells, BD Brooke, I. Bermudez, AK Jones: The neonicotinoid imidacloprid, and the pyrethroid deltamethrin, are antagonists of the insect Rdl GABA receptor. In: Journal of neurochemistry. Volume 135, Number 4, November 2015, pp. 705-713, doi : 10.1111 / jnc.13290 , PMID 26296809 .
- ↑ T. Nakao, S. Banba: Broflanilide: A meta-diamide insecticide with a novel mode of action. In: Bioorganic & medicinal chemistry. Volume 24, Number 3, February 2016, pp. 372-377, doi : 10.1016 / j.bmc.2015.08.008 , PMID 26361738 .
- ↑ RM Kwiatkowska, N. Platt, R. Poupardin, H. Irving, RK Dabire, S. Mitchell, CM Jones, A. Diabaté, H. Ranson, CS Wondji: Dissecting the mechanisms responsible for the multiple insecticide resistance phenotype in Anopheles gambiae ss, M form, from Vallée du Kou, Burkina Faso. In: Genes. Volume 519, number 1, April 2013, pp. 98-106, doi : 10.1016 / j.gene.2013.01.036 , PMID 23380570 , PMC 3611593 (free full text).
- ↑ CS Wondji, RK Dabire, Z. Tukur, H. Irving, R. Djouaka, JC Morgan: Identification and distribution of a GABA receptor mutation conferring dieldrin resistance in the malaria vector Anopheles funestus in Africa. In: Insect biochemistry and molecular biology. Volume 41, number 7, July 2011, pp. 484-491, doi : 10.1016 / j.ibmb.2011.03.012 , PMID 21501685 , PMC 3579012 (free full text).
- ↑ T. Nakao, S. Banba, M. Nomura, K. Hirase: Meta-diamide insecticides acting on distinct sites of RDL GABA receptor from those for conventional noncompetitive antagonists. In: Insect biochemistry and molecular biology. Volume 43, number 4, April 2013, pp. 366-375, doi : 10.1016 / j.ibmb.2013.02.002 , PMID 23416568 .