Receptor Tyrosine Kinase Ret

Receptor Tyrosine Kinase Ret
Properties of human protein
Mass / length primary structure	1086 amino acids
Secondary to quaternary structure	single-pass membrane protein
Cofactor	Ca 2+
Isoforms	RET51, RET43, RET9
Identifier
Gene name	RET
External IDs	OMIM : 164761 ; UniProt : P07949 ;
Enzyme classification
EC, category	2.7.10.1 , protein kinase
Response type	Phosphorusylation of tyrosine residues
Substrate	ATP + protein L-tyrosine
Products	ADP + protein L-tyrosine phosphate
Occurrence
Parent taxon	Vertebrates

The receptor tyrosine kinase Ret is a protein in the cell membrane of vertebrate cells . As a receptor tyrosine kinase , Ret has the task of transmitting the signal that is created by the docking of a ligand to the receptor area of Ret into the interior of the cell. There catalyzes then the kinase - domain of Ret the phosphorylation of other specific proteins, thereby signaling cascade is produced. These signals are indispensable during embryonic development for the precisely coordinated differentiation of certain neurons of the autonomic nervous system as well as kidney cells . Mutations in the RET - gene , which result in a loss of Ret function, are a cause of congenital megacolon , Ondine's curse and renal agenesis .

Ret seems to have no function in the adult organism, but mutations in the RET gene that lead to persistent enzyme activity are associated with a number of tumors : colon cancer , medullary thyroid carcinoma , papillary thyroid carcinoma (PTC), multiple endocrine neoplasia types 2A and 2B (MEN2A, MEN2B), increased risk of pheochromocytoma . The RET gene is therefore one of the proto-oncogenes .

literature

Honma Y, Kawano M, Kohsaka S, Ogawa M: Axonal projections of mechanoreceptive dorsal root ganglion neurons depend on Ret . In: Development . 137, No. 14, July 2010, pp. 2319-28. doi : 10.1242 / dev.046995 . PMID 20534675 .
Uesaka T, Enomoto H: Neural precursor death is central to the pathogenesis of intestinal aganglionosis in Ret hypomorphic mice . In: J. Neurosci. . 30, No. 15, April 2010, pp. 5211-8. doi : 10.1523 / JNEUROSCI.6244-09.2010 . PMID 20392943 .
Golden JP, Hoshi M, Nassar MA, et al. : RET signaling is required for survival and normal function of nonpeptidergic nociceptors . In: J. Neurosci. . 30, No. 11, March 2010, pp. 3983-94. doi : 10.1523 / JNEUROSCI.5930-09.2010 . PMID 20237269 . PMC 2850282 (free full text).
Jain S, Node A, Hoshi M, et al. : Organotypic specificity of key RET adapter-docking sites in the pathogenesis of neurocristopathies and renal malformations in mice . In: J. Clin. Invest. . 120, No. 3, March 2010, pp. 778-90. doi : 10.1172 / JCI41619 . PMID 20160347 . PMC 2827965 (free full text).
Fleming, Michael S., et al. "Cis and trans RET signaling control the survival and central projection growth of rapidly adapting mechanoreceptors." Elife 4 (2015): e06828.