Rho kinase 1
| Rho kinase 1 | ||
|---|---|---|
| Properties of human protein | ||
| Mass / length primary structure | 1354 amino acids | |
| Identifier | ||
| Gene name | ROCK1 | |
| External IDs | ||
| Enzyme classification | ||
| EC, category | 2.7.11.1 , protein kinase | |
| Response type | Phosphorylation | |
| Substrate | Add1, Cnn1, Des, Depysl2, Eef1a1, Ezr, Gfap, Limk1, Limk2, Marks, MRCL3, Msn, Nefl, Pfn2, Ppp1r12a, Ppp1r14a, Pten, Rdx, Slc9a1, Tnni3, Tnnt2, Vim | |
| Occurrence | ||
| Homology family | SKIRT | |
| Parent taxon | Bilateria | |
Rho kinase 1 (gene: ROCK1 ) is an enzyme that activates several other enzymes through phosphorylation as soon as it has bonded with the small G protein Rho A. It is therefore an essential part of signal transduction . Rho kinase is involved in regulating various cell functions such as the contraction of smooth muscle , the organization of the actin - cytoskeleton , the cell adhesion , the cell migration , of cytokinesis , the cell proliferation and the migration of inflammatory cells.
The Rho kinases evolved with the bilateral animals . In humans, Rho kinase 1 is located in the cytoplasm , in the membrane of the Golgi apparatus and in the centrioles during the S phase , but especially in platelets . Freshly formed Rho kinase 1 inhibits itself by binding the catalytic center to the C terminus. This inhibition is lifted by binding to Rho (reversible) or by severing the end (irreversible). This separation is catalyzed by the enzyme caspase-3 , especially during cell death , which ultimately causes the membrane to bulge ( blebbing ).
Fasudil hydrochloride is a specific inhibitor of Rho kinase.
swell
- ↑ MF Olson: ROCK1 AfCS-Nature Molecule Pages. 2006. doi : 10.1038 / mp.a002088.01 .
- ↑ G.-P. Sun et al .: Involvement of Rho-Kinase and TGF-beta Pathways in Aldosterone-Induced Renal Injury In: J Am Soc Nephrol . 2006 17: 2193-2201
- ↑ a b UniProt Q13464