Richard D. Kolodner

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Richard David Kolodner (born April 3, 1951 in Morristown , New Jersey ) is an American geneticist , biochemist and molecular biologist at the University of California, San Diego and at the Ludwig Institute for Cancer Research .

Life

Kolodner earned a BA from the University of California, Irvine in 1971 and a Ph.D. in 1975. at KK Tewari. His doctoral thesis was entitled The structure and metabolism of normal and variant forms of human serum Alpha-1-Antitrypsin . As a postdoctoral fellow , he worked with CC Richardson at Harvard Medical School , until he received his first professorship (1978 Assistant Professor , 1983 Associate Professor ) for biochemistry there and at the Dana-Farber Cancer Institute , and from 1987 also for molecular pharmacology . In 1981 Kolodner took over the management of the Department of Molecular Genetics at the Dana-Farber Cancer Institute , in 1988 he moved to the Cell and Molecular Biology department there as a full professor, and in 1990 he also took over the management of the Department of X-ray Crystallography . In 1991 he was appointed to the chair of cell and molecular biology at the Dana-Farber Cancer Institute , and in 1995 he switched to the chair of human cancer genetics there .

In 1997 Kolodner moved to the Ludwig Institute for Cancer Research in La Jolla , San Diego , California , where he is now (as of 2016) Head of Cancer Genetics. At the same time he holds a professorship in internal medicine at the University of California, San Diego . He runs his research laboratory together with Christopher Putnam .

Act

Kolodner was able to work out the importance of disorders of the DNA mismatch repair proteins , in particular Msh2 , for the development of cancer . ( Shortly after Kolodner (1993) Bert Vogelstein was also able to identify the gene for Msh2 in humans.) Kolodner's work also deals with other mechanisms of DNA repair and their significance for the development of cancer. Kolodner and co-workers use Saccharomyces cerevisiae as a model organism and link the results with the role of the corresponding homologous genes in humans in the development of cancer. Another field of activity are studies on the genetic cause of the Cold Induced Autoinflammatory Syndrome (mutation in the NALP3 gene, see Inflammasome ) and Congenital Tufting Enteropathy (mutation in the EpCAM gene, see Epithelial cell adhesion molecule ).

Kolodner has published more than 275 scientific publications (as of 2016) . He was a member of numerous scientific commissions and advisory boards. He was a co-editor of the scientific journals Cell , Molecular and Cellular Biology , Journal of Biological Chemistry and DNA Repair .

Awards (selection)

Web links

Individual evidence

  1. ^ Curriculum vitae, status at the end of 1995 (PDF, 149 kB) at Carnegie Mellon University (cmu.edu); accessed on August 13, 2016.
  2. ↑ General Motors Cancer Research Awards Laureates 1979–1998 (PDF; 106 kB) at aacrjournals.org; accessed on August 13, 2016.
  3. ↑ Richard Kolodner. In: nasonline.org. Retrieved August 13, 2016 .
  4. ↑ Book of Members 1780 – present (PDF, 695 kB) at the American Academy of Arts and Sciences (amacad.org); accessed on August 13, 2016.
personal data
SURNAME Kolodner, Richard D.
ALTERNATIVE NAMES Kolodner, Richard; Kolodner, Richard David
BRIEF DESCRIPTION American geneticist, biochemist, and molecular biologist
DATE OF BIRTH April 3, 1951
PLACE OF BIRTH Morristown, New Jersey