Ronald R. Breaker
Ronald R. Breaker (* 1964 in Tigerton , Wisconsin ) is an American molecular biologist at Yale University .
Life
Breaker earned a bachelor's degree in biology and chemistry from the University of Wisconsin at Stevens Point in 1987 and a Ph.D. in 1992 from Peter Gilham at Purdue University in West Lafayette, Indiana. in biochemistry . As a postdoctoral fellow , he worked with Gerald Joyce at the Scripps Research Institute in La Jolla , California . Breaker has been at Yale University in New Haven (Connecticut) since 1995 , where he is now (as of 2012) Professor of Molecular , Cellular and Developmental Biology and Professor of Molecular Biophysics . Breaker is also doing research for the Howard Hughes Medical Institute .
Act
With the riboswitch, Breaker discovered a mechanism in which metabolites regulate their own synthesis through direct binding to the mRNA that encodes them . Riboswitches are therefore potential target molecules for novel drugs and could regulate genes that have been introduced into cells using gene therapy .
Breaker succeeded for the first time in the synthesis of an enzymatically effective DNA , a so-called deoxyribozyme - the counterpart of an enzymatically effective RNA is called a ribozyme . Breaker’s further research is concerned with other forms of non-coding RNA and the role of RNA in evolution (see also RNA world hypothesis ).
Awards (selection)
- 2004 Fellow of the American Association for the Advancement of Science
- 2005 Eli Lilly and Company Research Award
- 2006 NAS Award in Molecular Biology
- 2013 member of the National Academy of Sciences
Web links
- Ronald R. Breaker - Profile and Biography at Yale University (yale.edu)
- The Breaker Lab and Ronald Breaker at Yale University (yale.edu)
- Ronald R. Breaker, Ph.D. and Research Abstract at the Howard Hughes Medical Institute (hhmi.org)
- Ronald R. Breaker on Chemical & Engineering News on March 23, 2004 (pubs.acs.org)
Individual evidence
- ^ RR Breaker: In Vitro Selection of Catalytic Polynucleotides. In: Chemical Reviews . Volume 97, Number 2, April 1997, pp. 371-390, ISSN 1520-6890 . PMID 11848875 .
- ^ Eli Lilly and Company-Elanco Research Award Past Laureates. (No longer available online.) In: asm.org. January 12, 2016, archived from the original on February 1, 2016 ; accessed on February 1, 2016 .
- ^ NAS Award in Molecular Biology. In: nasonline.org. Retrieved January 13, 2016 .
| personal data | |
|---|---|
| SURNAME | Breaker, Ronald R. |
| BRIEF DESCRIPTION | American molecular biologist |
| DATE OF BIRTH | 1964 |
| PLACE OF BIRTH | Tigerton , Wisconsin |